The 1941 Wiley Wildcats football team represented Wiley College as a member of the Southwestern Athletic Conference (SWAC) during the 1941 college football season. Led by 19th-year head coach Fred T. Long, the Wildcats compiled an overall record of 1–6–1, with a conference record of 0–5–1, tying for sixth place at the bottom of the SWAC standings.
Prairie View's conference title was forfeited after the SWAC ruled at its winter meeting, on December 13, that the Panthers had used an ineligible player, Whiteside.