ZFYVE28

Zinc finger FYVE-type containing 28 is a protein that in humans is encoded by the ZFYVE28 gene.

ZFYVE28
Identifiers
Aliases	ZFYVE28, LST2, LYST2, zinc finger FYVE-type containing 28, lst-2
External IDs	OMIM: 614176; MGI: 2684992; HomoloGene: 15119; GeneCards: ZFYVE28; OMA:ZFYVE28 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4p16.3 Start 2,269,582 bp End 2,418,651 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 B2 Start 34,352,237 bp End 34,445,793 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum granulocyte right frontal lobe Brodmann area 9 mucosa of transverse colon anterior cingulate cortex testicle nucleus accumbens body of stomach prefrontal cortex Top expressed in neural layer of retina cerebellar cortex lumbar spinal ganglion superior frontal gyrus lobe of cerebellum cerebellar vermis piriform cortex olfactory tubercle primary visual cortex dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding phosphatidylinositol-3-phosphate binding metal ion binding Cellular component cytoplasm cytosol endosome early endosome membrane membrane Biological process negative regulation of epidermal growth factor-activated receptor activity negative regulation of epidermal growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57732 231125 Ensembl ENSG00000159733 ENSMUSG00000037224 UniProt Q9HCC9 Q6ZPK7 RefSeq (mRNA) NM_001172656 NM_001172657 NM_001172658 NM_001172659 NM_001172660 NM_020972 NM_001015039 RefSeq (protein) NP_001166127 NP_001166128 NP_001166129 NP_001166130 NP_001166131 NP_066023 NP_001015039 Location (UCSC) Chr 4: 2.27 – 2.42 Mb Chr 5: 34.35 – 34.45 Mb PubMed search
Wikidata
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Further reading

• Mosesson Y, Chetrit D, Schley L, Berghoff J, Ziv T, Carvalho S, Milanezi F, Admon A, Schmitt F, Ehrlich M, Yarden Y (2009). "Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling". Dev. Cell. 16 (5): 687–98. doi:10.1016/j.devcel.2009.03.015. PMC 3356849. PMID 19460345.