Wikipedia

X. Peter Zhang

X. Peter Zhang (Xiao-Xiang Peter Zhang) is an organic chemist and professor of chemistry at Boston College.[1] His research focuses on stereoselective organic synthesis, radical chemistry, and catalysis, including the development of metalloradical catalysis using cobalt and iron complexes.[1][2]

X. Peter Zhang
Alma materAnhui Normal University (B.S.)
Beijing Normal University (M.S.)
University of Pennsylvania (Ph.D.)
Known forMetalloradical catalysis
Cobalt(II)–porphyrin catalysis
Stereoselective radical reactions
Asymmetric catalysis
AwardsORAU Ralph Powe Junior Faculty Award (2003)
NSF CAREER Award (2006)
Thieme Chemistry Journals Award (2009)
Scientific career
FieldsOrganic chemistry, Catalysis, Radical chemistry
InstitutionsUniversity of Tennessee
University of South Florida
Boston College
Bradford B. Wayland

Education and career

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Zhang received a B.S. from Anhui Normal University in 1985 and an M.S. from Beijing Normal University in 1988. He earned his Ph.D. in chemistry from the University of Pennsylvania in 1996 under the supervision of Bradford B. Wayland.[3][4]

After completing his doctorate, Zhang held postdoctoral appointments at the Massachusetts Institute of Technology, first with Stephen J. Lippard from 1996 to 1999 and then with Stephen L. Buchwald from 1999 to 2001.[3][4] He began his academic career at the University of Tennessee in 2001. He later joined the University of South Florida, where he was promoted to full professor, before joining the faculty at Boston College in 2015.[3]

Research

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Zhang's research focuses on the following areas:

  1. Metalloradical catalysis and catalyst design. Zhang's group develops metalloradical catalysis as an approach for controlling radical reactivity and stereoselectivity in organic synthesis.[2] Reviews of enantioselective radical chemistry have discussed metalloradical catalysis as one strategy within transition-metal-catalyzed radical reactions.[5] A major component of this work involves cobalt(II) porphyrin complexes and chiral porphyrin ligand design, including modular chiral porphyrins and D2-symmetric chiral amidoporphyrins.[6]
  2. Asymmetric radical transformations of alkenes. Zhang's laboratory has applied cobalt-based metalloradical catalysis to stereoselective alkene functionalization, including cyclopropanation and aziridination.[7] His chiral cobalt(II)–porphyrin cyclopropanation chemistry was highlighted in a 2009 Angewandte Chemie commentary by Michael P. Doyle.[8] Asymmetric cyclopropanation has also been reviewed in the broader synthetic chemistry literature.[9] His group's iron-based metalloradical cyclopropanation work was accompanied by a Nature Chemistry Research Briefing.[10]
  3. C–H functionalization and C–N bond formation. Zhang's group has reported metalloradical methods for C–H functionalization, including asymmetric C–H alkylation through 1,4-hydrogen atom abstraction, intermolecular radical C–H amination, and allylic C–H amination.[11] The allylic C–H amination work was also covered by EurekAlert!.[12] Broader transition-metal-catalyzed C(sp3)–N(sp3) bond-forming reactions have also been reviewed in the catalysis literature.[13] Other reported applications from the group include radical and radical/ionic approaches to β-functionalized amines and radical dearomative conjugate amination.[14]

Awards and honors

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References

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  1. 1 2 3 "Faculty Directory: X. Peter Zhang". Boston College. Retrieved 8 July 2026.
  2. 1 2 Lee, W.-C. C.; Zhang, X. P. (2024). "Metalloradical Catalysis: General Approach for Controlling Reactivity and Selectivity of Homolytic Radical Reactions". Angewandte Chemie International Edition. 63: e202320243. doi:10.1002/anie.202320243.{{cite journal}}: CS1 maint: article number as page number (link)
  3. 1 2 3 4 "People: X. Peter Zhang". Boston College. Retrieved 8 July 2026.
  4. 1 2 "X. Peter Zhang". Chem-Station. 13 May 2019. Retrieved 8 July 2026.
  5. ↑ Mondal, S.; Dumur, F.; Gigmes, D.; Sibi, M. P.; Bertrand, M. P.; Nechab, M. (2022). "Enantioselective Radical Reactions Using Chiral Catalysts". Chemical Reviews. 122 (6): 5842–5976. doi:10.1021/acs.chemrev.1c00582.
  6. ↑ Chen, Y.; Fields, K. B.; Zhang, X. P. (2004). "Bromoporphyrins as Versatile Synthons for Modular Construction of Chiral Porphyrins: Cobalt-Catalyzed Highly Enantioselective and Diastereoselective Cyclopropanation". Journal of the American Chemical Society. 126: 14718–14719. doi:10.1021/ja044889l.
  7. ↑ Zhu, S.; Perman, J. A.; Zhang, X. P. (2008). "Acceptor/Acceptor-Substituted Diazo Reagents for Carbene Transfers: Cobalt-Catalyzed Asymmetric Z-Cyclopropanation of Alkenes with α-Nitrodiazoacetates". Angewandte Chemie International Edition. 47 (44): 8460–8463. doi:10.1002/anie.200803857.
  8. ↑ Doyle, M. P. (2009). "Exceptional Selectivity in Cyclopropanation Reactions Catalyzed by Chiral Cobalt(II)-Porphyrin Catalysts". Angewandte Chemie International Edition. 48 (5): 850–852. doi:10.1002/anie.200804940. PMID 19117005.
  9. ↑ Pellissier, H. (2008). "Recent Developments in Asymmetric Cyclopropanation". Tetrahedron. 64: 7041–7095. doi:10.1016/j.tet.2008.04.079.
  10. ↑ Lee, W.-C. C.; Wang, D.-S.; Zhu, Y.-L.; Zhang, X. P. (2023). "Iron(III)-Based Metalloradical Catalysis for Asymmetric Cyclopropanation via a Stepwise Radical Mechanism". Nature Chemistry. 15: 1569–1580. doi:10.1038/s41557-023-01317-8.
  11. ↑ Xie, J.-J.; Xu, P.; Zhu, Y.-L.; Wang, J.-Y.; Lee, W.-C. C.; Zhang, X. P. (2021). "New Catalytic Radical Process Involving 1,4-Hydrogen Atom Abstraction: Asymmetric Construction of Cyclobutanones". Journal of the American Chemical Society. 143: 11670–11678. doi:10.1021/jacs.1c04968.
  12. ↑ "Metalloradical Catalysis Guides New Cobalt-Based System That Exploits Unique Features of Homolytic Radical Reaction". EurekAlert!. 12 January 2023. Retrieved 8 July 2026.
  13. ↑ Jia, J.-S.; Bhat, M.-u.-S.; Tian, L.; Zhang, H.-R.; Li, Y.-L.; Yu, Q.; Shu, W. (2026). "Recent Progress in Transition-Metal-Catalysed Intermolecular Saturated C(sp3)–N(sp3) Bond Formation Reactions". Chemical Society Reviews. 55: 3469–3598. doi:10.1039/D5CS00923E.
  14. ↑ Lang, K.; Hu, Y.; Lee, W.-C. C.; Zhang, X. P. (2022). "Combined Radical and Ionic Approach for the Enantioselective Synthesis of β-Functionalized Amines from Alcohols". Nature Synthesis. 1: 548–557. doi:10.1038/s44160-022-00107-3.
  15. ↑ "Thieme Chemistry Journals Award - Previous Winners". Thieme Group. Retrieved 8 July 2026.
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