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Article Draft
editFunction
editProtein Structure
editMucoproteins are composed of o-linked carbohydrates as well as highly glycosylated proteins, which are held together by disulfide bonds[2]. The viscosity of the mucus depends on the strength of the disulfide bonds. When these disulfide bonds are broken, the viscosity of the mucus secretions is reduced.
Clinical Significance
editMucolytic medications will break through the disufide bonds and lower the viscosity of the mucus, thus allowing the hypersecreted mucus to bemore managable. A hypersectretion of mucus is often a symptom of pulmonary diseases or respiratory infections.[3]
There are two subgroups in mycolytic medications and each one works differently to control the hypersecreted mucus.
- Classic mucolytic medications these medications change the disulfide bond by reducing it to a thiol bond, thus thoroughly breaking down the mucoproteins and making the mucus more managable.
- Peptide mucolytic medications these medications depolymerize DNA polymer and F-actin links that are present when the mucus hypersecretes. This preserves the mucins that are helpful to the epithelial tissue of the lungs.[4]
Bibliography
edit- Aksoy, Murat; Aydin Faruk; Guven, Suleyman; Kart, Cavit; Tosun, Ilknur (2012). "The effect of ethinyl estradiol and drospirenone-containing oral contraceptives upon mucoprotein content of cervical mucus." ScienceDirect. [2]
- Aronson, J. K., ed. (2016-01-01). "Acetylcysteine", Meyer's Side Effects on Drugs (Sixteenth Edition), Oxford: Elsevier, pp 23-25.[3]
- Gupta, Rishab; Wadhwa, Roopma (2022). "Mucolytic Medications." National Library of Medicine.[4]
- Cone, Richard A (2009). "Barrier properties of mucus." ScienceDirect.[1]
References
edit- 1 2 Cone, Richard A. (2009-02-27). "Barrier properties of mucus". Advanced Drug Delivery Reviews. 61 (2): 75–85. doi:10.1016/j.addr.2008.09.008. ISSN 0169-409X.
- 1 2 Aksoy, Murat; Guven, Suleyman; Tosun, Ilknur; Aydın, Faruk; Kart, Cavit (2012-09-01). "The effect of ethinyl estradiol and drospirenone-containing oral contraceptives upon mucoprotein content of cervical mucus". European Journal of Obstetrics & Gynecology and Reproductive Biology. 164 (1): 40–43. doi:10.1016/j.ejogrb.2012.05.002. ISSN 0301-2115.
- 1 2 "Acetylcysteine", Meyler's Side Effects of Drugs, Elsevier, pp. 23–25, 2016, retrieved 2022-05-06
- 1 2 Gupta, Rishab; Wadhwa, Roopma (2022), "Mucolytic Medications", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 32644589, retrieved 2022-05-06