Tulane virus (Recovirus tulani) is a calicivirus isolated from the rhesus monkey.[2] It is the sole member of the Recovirus genus.[3] It is a non-enveloped, positive-sense, single-stranded RNA virus, and its genome, which is approximately 6.7 kilobases in length, is reported shortest among the members of the family Caliciviridae . The genome is organized into three open reading frames (ORFs): ORF1 encodes a nonstructural polyprotein involved in viral replication, ORF2 endcodes the major capsid protein (VP1), and ORF3 encodes a basic minor structural protein (VP2)[4].
| Tulane virus | |
|---|---|
Virus classification  | |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Pisuviricota |
| Class: | Pisoniviricetes |
| Order: | Picornavirales |
| Family: | Caliciviridae |
| Genus: | Recovirus |
| Species: | Recovirus tulani |
| Synonyms[1] | |
| |
The virus was first identified in 2008 after being isolated from the stool samples of captive juvenile rhesus macaques (Macaca mulatta) housed at the Tulane National Primate Research Center[4]. It propagates easily in cell lines such as LLC-MK2[5], and recognizes histo-blood group antigens (HBGAs) similar to human noroviruses (HuNoVs)[6]. These features make it a good surrogate candidate for HuNoV studies.
References
edit- ↑ "History of the taxon: Species: Recovirus tulani (2024 Release, MSL #40)". International Committee on Taxonomy of Viruses. Retrieved 20 March 2025.
- ↑ Farkas, Tibor (1 July 2015). "Rhesus enteric calicivirus surrogate model for human norovirus gastroenteritis". Journal of General Virology. 96 (7): 1504–1514. doi:10.1099/jgv.0.000020. PMID 25502652.
- ↑ "Genus: Recovirus - Caliciviridae - Positive-sense RNA Viruses". International Committee on Taxonomy of Viruses (ICTV). Archived from the original on August 29, 2021. Retrieved 3 September 2020.
- 1 2 Farkas, Tibor; Sestak, Karol; Wei, Chao; Jiang, Xi (June 2008). "Characterization of a Rhesus Monkey Calicivirus Representing a New Genus of Caliciviridae". Journal of Virology. 82 (11): 5408–5416. doi:10.1128/jvi.00070-08.
- ↑ Chhabra, Preeti; Ranjan, Priya; Cromeans, Theresa; Sambhara, Suryaprakash; Vinjé, Jan (2017-05-01). "Critical role of RIG-I and MDA5 in early and late stages of Tulane virus infection". Journal of General Virology. 98 (5): 1016–1026. doi:10.1099/jgv.0.000769. ISSN 0022-1317. PMC 5916764. PMID 28530548.
- ↑ Zhang, Dongsheng; Huang, Pengwei; Zou, Lu; Lowary, Todd L.; Tan, Ming; Jiang, Xi (2014-01-02). "Tulane Virus Recognizes the A Type 3 and B Histo-Blood Group Antigens". Journal of Virology. 89 (2): 1419–1427. doi:10.1128/jvi.02595-14.
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