Wikipedia

Template:Psilocin activities

Psilocin at molecular targets
TargetAffinity (Ki, nM)
5-HT1A49–567 (Ki)
130–>3,160 (EC50Tooltip half-maximal effective concentration)
0.7%–96% (EmaxTooltip maximal efficacy)
5-HT1B31–305
5-HT1D19–36
5-HT1E44–52
5-HT1FND
5-HT2A6.0–340 (Ki)
2.4–3,836 (EC50)
16–98% (Emax)
5-HT2B4.6–410 (Ki)
2.4–>20,000 (EC50)
1.4–84% (Emax)
5-HT2C10–141 (Ki)
9.1–30 (EC50)
86–95% (Emax)
5-HT3>10,000
5-HT4ND
5-HT5A70–84
5-HT657–72
5-HT73.5–72
α1A–α1B>10,000
α2A1,379–2,044
α2B1,271–1,894
α2C4,404
β1–β2>10,000
D120–>14,000
D23,700–>10,000
D3101–8,900
D4>10,000
D5>10,000
H11,600–>10,000
H2–H4>10,000
M1–M5>10,000
σ1>10,000
σ2>10,000
I2792
TAAR11,400 (Ki) (rat)
17,000 (Ki) (mouse)
920–2,700 (EC50) (rodent)
>30,000 (EC50) (human)
SERTTooltip Serotonin transporter3,650–>10,000 (Ki)
662–3,900 (IC50Tooltip half-maximal inhibitory concentration)
561 (EC50)
54% (Emax)
NETTooltip Norepinephrine transporter13,000 (Ki)
14,000 (IC50)
>10,000 (EC50)
DATTooltip Dopamine transporter6,000–>30,000 (Ki)
>100,000 (IC50)
>10,000 (EC50)
Notes: The smaller the value, the more avidly psilocin interacts with the site. Sources: [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]
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