| Pos | Team | Pld | W | D | L | B | PF | PA | PD | Pts | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  Melbourne Storm (M) |
24 | 21 | 0 | 3 | 1 | 815 | 316 | +499 | 44 | Advance to finals series |
| 2 |  Penrith Panthers (P) |
24 | 21 | 0 | 3 | 1 | 676 | 286 | +390 | 44 | |
| 3 |  South Sydney Rabbitohs |
24 | 20 | 0 | 4 | 1 | 775 | 453 | +322 | 42 | |
| 4 |  Manly-Warringah Sea Eagles |
24 | 16 | 0 | 8 | 1 | 744 | 492 | +252 | 34 | |
| 5 |  Sydney Roosters |
24 | 16 | 0 | 8 | 1 | 630 | 489 | +141 | 34 | |
| 6 |  Parramatta Eels |
24 | 15 | 0 | 9 | 1 | 566 | 457 | +109 | 32 | |
| 7 |  Newcastle Knights |
24 | 12 | 0 | 12 | 1 | 428 | 571 | −143 | 26 | |
| 8 |  Gold Coast Titans |
24 | 10 | 0 | 14 | 1 | 580 | 583 | −3 | 22 | |
| 9 |  Cronulla-Sutherland Sharks |
24 | 10 | 0 | 14 | 1 | 520 | 556 | −36 | 22 | |
| 10 |  Canberra Raiders |
24 | 10 | 0 | 14 | 1 | 481 | 578 | −97 | 22 | |
| 11 |  St. George Illawarra Dragons |
24 | 8 | 0 | 16 | 1 | 474 | 616 | −142 | 18 | |
| 12 |  New Zealand Warriors |
24 | 8 | 0 | 16 | 1 | 453 | 624 | −171 | 18 | |
| 13 |  Wests Tigers |
24 | 8 | 0 | 16 | 1 | 500 | 714 | −214 | 18 | |
| 14 |  Brisbane Broncos |
24 | 7 | 0 | 17 | 1 | 446 | 695 | −249 | 16 | |
| 15 |  North Queensland Cowboys |
24 | 7 | 0 | 17 | 1 | 460 | 748 | −288 | 16 | |
| 16 |  Canterbury-Bankstown Bulldogs (W) |
24 | 3 | 0 | 21 | 1 | 340 | 710 | −370 | 8 |
Updated to match(es) played on 5 September 2021. Source: 2021 NRL Ladder
(M) Minor premiers; (P) Premiers; (W) Wooden spoon
(M) Minor premiers; (P) Premiers; (W) Wooden spoon