Talk:Kenneth S. Kosik
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Addition of Research section (new)
edit | This edit request by an editor with a conflict of interest was declined. |
- What I think should be changed (include citations):
Research section (new):
- Addition of research section that outlines the multiple topics researched by Kosik lab.
Updated version:
Kenneth Kosik’s research focuses on the underlying molecular basis of plasticity, particularly how protein translation at the synapse affects learning and how impairments of plasticity lead to neurodegenerative diseases[1]. Beginning in the early nineties, Kosik contributed toward the characterization of the largest familial Alzheimer kindred in the world, a large family in Colombia with dementia onset at an early age. At that time none of the current research facilities existed there. This began a longterm collaboration with Francisco Lopera in which the family trees were assembled, the neuropathological proof of Alzheimer’s disease obtained, the gene mutation discovered, the first brain imaging performed, and specialized neuropsychological testing devised. Kosik’s work with early onset familial Alzheimer’s disease in Colombia was the basis for a novel prevention trial to treat Alzheimer’s disease, and his efforts stimulated many discoveries and catalyzed research by a diverse group of experts who contributed to elaborating complex facets of this unique population[2].
In 1986, Kosik was one of several groups that independently discovered Tau protein in the Alzheimer neurofibrillary tangle, followed up with many studies on the biology and pathobiology of Tau[3]. Kosik showed the loss of polarity in tangle-bearing neurons and published the first cloning of human tau, identification of its microtubule binding domain, the first description that tau splicing was developmentally regulated, the localization of tau mRNA, and the identification of a human tau promoter [4]. He defined a role for tau in axonal elaboration and neuronal polarity, and he discovered that the inhibition of farnesyl transferase ameliorates tau pathology in animal models[5].
Most recently, he discovered the receptor LRP1 is involved in tau uptake and spread, which are looked upon as the basis for target identification and drug discovery[6]. Kosik’s research has also described how RNA moves in neurons as RNA granules called droplets that contain a distinct liquid-liquid phase separated state[7][8]. Furthermore, he has identified a role for miRNAs in exit from pluripotency and discovered a set of cellular programs that harbinger a neuro-ectodermal fate[9]. Kosik has also identified one of the earliest expression dysfunctions in Williams syndrome using induced pluripotent stem cells[10], and his detailed studies of delta-catenin all directly from the Kosik lab revealed a remarkable set of findings[11][12].
- Why it should be changed:
- Addition of Research section to expand upon research background.
NRI-gaucho (talk) 02:38, 26 September 2025 (UTC)
References
- ↑ https://www.stemcell.ucsb.edu/people/kosik.
{{cite web}}: Missing or empty|title=(help) - ↑ https://wiley.scienceconnect.io/api/oauth/authorize?ui_locales=en&scope=affiliations+alm_identity_ids+merged_users+openid+session_level+settings&response_type=code&redirect_uri=https%3A%2F%2Fnyaspubs.onlinelibrary.wiley.com%2Faction%2FoidcCallback%3FidpCode%3Dconnect&state=Dps2IO0LOrpSUAYYguc7KjWtugvQmVzeWJ3Swlsnw8%2BNWmPgxdoFhonB7b3DqEKrtx8zwixDvPZ0HkWpXWlu%2BjXb5uVKo2JiQq%2FsfEdJUaYr0DCQbGIyvDMny1OwA%2F%2B0brQH6AcQ3lbUPgZMr52e28XoGZK2QOLBTlvIHgeKa78%3D&prompt=none&nonce=vcKir%2B%2FEgL1ioPSu%2BPd5S1zMLJ6EWq0cNx2b7ULDG1o%3D&client_id=wiley.
{{cite web}}: Missing or empty|title=(help) - ↑ https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1750-3639.1993.tb00724.x?sid=nlm%3Apubmed.
{{cite web}}: Missing or empty|title=(help) - ↑ https://pubs.acs.org/doi/abs/10.1021/bi00158a027.
{{cite web}}: Missing or empty|title=(help) - ↑ https://pmc.ncbi.nlm.nih.gov/articles/PMC7961212/.
{{cite web}}: Missing or empty|title=(help) - ↑ https://www.nature.com/articles/s41586-020-2156-5.
{{cite web}}: Missing or empty|title=(help) - ↑ https://www.jneurosci.org/content/16/24/7812.long.
{{cite web}}: Missing or empty|title=(help) - ↑ https://www.jneurosci.org/content/41/5/834.
{{cite web}}: Missing or empty|title=(help) - ↑ https://www.cell.com/cell/pdf/S0092-8674(10)01018-4.pdf.
{{cite web}}: Missing or empty|title=(help) - ↑ https://academic.oup.com/hmg/article/25/7/1294/2363186?login=false.
{{cite web}}: Missing or empty|title=(help) - ↑ https://www.cell.com/trends/neurosciences/fulltext/S0166-2236%2823%2900104-2.
{{cite web}}: Missing or empty|title=(help) - ↑ https://www.cell.com/trends/cell-biology/abstract/S0962-8924(05)00018-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0962892405000188%3Fshowall%3Dtrue.
{{cite web}}: Missing or empty|title=(help)
Not done: Duplicate request. Please avoid making duplicates as it won't speed up the request, but it does clog up the queue. Thanks Encoded Talk 💬 17:35, 21 December 2025 (UTC)
Addition of Biography section
edit | This edit request by an editor with a conflict of interest was declined. Some or all of the changes weren't supported by neutral, independent, reliable sources. Consider re-submitting with content based on media, books and scholarly works. |
- What I think should be changed (include citations):
Biography section (new):
- Addition of biography section that summarizes education, positions, and appointments.
Updated version:
Kenneth Kosik completed a B.A. and M.A. in English literature from Case Western Reserve University in 1972 and an M.D. from the Medial College of Pennsylvania in 1976. He served as a resident in neurology at Tufts New England Medical Center and was Chief Resident in 1980. From 1980 to 2004, he held a series of academic appointments at the Harvard Medical School and achieved the rank of full professor there in 1996. Kosik also held appointments at McLean Hospital, Brigham and Women’s Hospital, the Massachusetts General Hospital and the Dana-Farber Cancer Institute between 1980 and 2004. In 2004, Kosik became the Harriman Professor of Neuroscience Research, where he also serves as Co-Director of the Neuroscience Research Institute at the University of California, Santa Barbara. Kosik also currently co-directs the Tau Consortium, co-founded the Learning and the Brain Conference, and has a longstanding interest in the interface between neuroscience and education[1].
- Why it should be changed:
- Addition of Biography section to summarize professional background.
NRI-gaucho (talk) 02:41, 26 September 2025 (UTC)
References
- ↑ https://www.stemcell.ucsb.edu/people/kosik.
{{cite web}}: Missing or empty|title=(help)
- Not done: The changes are not supported by neutral, independent, reliable sources. Please provide reliable sources that support the change you want to be made. Likeanechointheforest (talk) 16:58, 29 September 2025 (UTC)
Addition of Biography section
edit | This edit request by an editor with a conflict of interest was declined. |
- What I think should be changed (include citations):
Biography section (new):
- Addition of biography section that summarizes education, positions, and appointments.
Updated version:
Kenneth Kosik completed a B.A. and M.A. in English literature from Case Western Reserve University in 1972 and an M.D. from the Medial College of Pennsylvania in 1976. He served as a resident in neurology at Tufts New England Medical Center and was Chief Resident in 1980. From 1980 to 2004, he held a series of academic appointments at the Harvard Medical School and achieved the rank of full professor there in 1996. Kosik also held appointments at McLean Hospital, Brigham and Women’s Hospital, the Massachusetts General Hospital and the Dana-Farber Cancer Institute between 1980 and 2004. In 2004, Kosik became the Harriman Professor of Neuroscience Research, where he also serves as Co-Director of the Neuroscience Research Institute at the University of California, Santa Barbara. Kosik also currently co-directs the Tau Consortium, co-founded the Learning and the Brain Conference, and has a longstanding interest in the interface between neuroscience and education[1].
- Why it should be changed:
- Addition of Biography section to summarize professional background.
2600:6C52:7E7F:FA18:986D:540A:595C:EF1B (talk) 18:36, 29 September 2025 (UTC)
References
- ↑ https://www.jdfaf.org/directory/2020/2/27/kenneth-kosik-md#:~:text=Kenneth%20S.,was%20Chief%20Resident%20in%201980.
{{cite web}}: Missing or empty|title=(help)
- Not done: duplicate request. GoldRomean (talk) 06:29, 18 December 2025 (UTC)
Addition of Research section
edit | Part of an edit requested by an editor with a conflict of interest has been implemented. |
- What I think should be changed (include citations):
Research section (new):
- Addition of research section that outlines the multiple topics researched by Kosik lab.
Updated version:
Kenneth Kosik’s research focuses on the underlying molecular basis of plasticity, particularly how protein translation at the synapse affects learning and how impairments of plasticity lead to neurodegenerative diseases [1]. Beginning in the early nineties, Kosik contributed toward the characterization of the largest familial Alzheimer kindred in the world, a large family in Colombia with dementia onset at an early age. At that time none of the current research facilities existed there. This began a longterm collaboration with Francisco Lopera in which the family trees were assembled, the neuropathological proof of Alzheimer’s disease obtained, the gene mutation discovered, the first brain imaging performed, and specialized neuropsychological testing devised. Kosik’s work with early onset familial Alzheimer’s disease in Colombia was the basis for a novel prevention trial to treat Alzheimer’s disease, and his efforts stimulated many discoveries and catalyzed research by a diverse group of experts who contributed to elaborating complex facets of this unique population [2].
In 1986, Kosik was one of several groups that independently discovered Tau protein in the Alzheimer neurofibrillary tangle, followed up with many studies on the biology and pathobiology of Tau [3]. Kosik showed the loss of polarity in tangle-bearing neurons and published the first cloning of human tau, identification of its microtubule binding domain, the first description that tau splicing was developmentally regulated, the localization of tau mRNA, and the identification of a human tau promoter [4]. He defined a role for tau in axonal elaboration and neuronal polarity, and he discovered that the inhibition of farnesyl transferase ameliorates tau pathology in animal models[5].
Most recently, he discovered the receptor LRP1 is involved in tau uptake and spread, which are looked upon as the basis for target identification and drug discovery [6]. Kosik’s research has also described how RNA moves in neurons as RNA granules called droplets that contain a distinct liquid-liquid phase separated state [7][8]. Furthermore, he has identified a role for miRNAs in exit from pluripotency and discovered a set of cellular programs that harbinger a neuro-ectodermal fate [9]. Kosik has also identified one of the earliest expression dysfunctions in Williams syndrome using induced pluripotent stem cells, [10] and his detailed studies of delta-catenin all directly from the Kosik lab revealed a remarkable set of findings [11][12].
- Why it should be changed:
- Addition of Research section to expand upon research background, which has changed over career.
NRI-gaucho (talk) 19:06, 20 October 2025 (UTC)
References
- ↑ "Kenneth S. Kosik". www.stemcell.ucsb.edu.
{{cite web}}: Text "UC Santa Barbara" ignored (help); Text "William K. Bowes Laboratory for Stem Cell Biology and Engineering" ignored (help) - ↑ Ramirez Aguilar, Laura; Acosta-Uribe, Juliana; Giraldo, Margarita M.; Moreno, Sonia; Baena, Ana; Alzate, Diana; Cuastumal, Rosario; Aguillón, David; Madrigal, Lucía; Saldarriaga, Amanda; Navarro, Alexander; Garcia, Gloria P.; Aguirre-Acevedo, Daniel C.; Geier, Ethan G.; Cochran, J. Nicholas; Quiroz, Yakeel T.; Myers, Richard M.; Yokoyama, Jennifer S.; Kosik, Kenneth S.; Lopera, Francisco (May 2019). "Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr)". Alzheimer's & Dementia: The Journal of the Alzheimer's Association. pp. 709–719. doi:10.1016/j.jalz.2018.12.010.
- ↑ Kosik, Kenneth S. (1993). "The Molecular and Cellular Biology of Tau". Brain Pathology. pp. 39–43. doi:10.1111/j.1750-3639.1993.tb00724.x.
- ↑ Andreadis, Athena; Brown, William M.; Kosik, Kenneth S. (1 November 1992). "Structure and novel exons of the human .tau. gene". Biochemistry. pp. 10626–10633. doi:10.1021/bi00158a027.
- ↑ Hernandez, Israel; Luna, Gabriel; Rauch, Jennifer N.; Reis, Surya A.; Giroux, Michel; Karch, Celeste M.; Boctor, Daniel; Sibih, Youssef E.; Storm, Nadia J.; Diaz, Antonio; Kaushik, Susmita; Zekanowski, Cezary; Kang, Alexander A.; Hinman, Cassidy R.; Cerovac, Vesna; Guzman, Elmer; Zhou, Honjun; Haggarty, Stephen J.; Goate, Alison M.; Fisher, Steven K.; Cuervo, Ana M.; Kosik, Kenneth S. (27 March 2019). "A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy". Science Translational Medicine. pp. eaat3005. doi:10.1126/scitranslmed.aat3005.
- ↑ Rauch, Jennifer N.; Luna, Gabriel; Guzman, Elmer; Audouard, Morgane; Challis, Collin; Sibih, Youssef E.; Leshuk, Carolina; Hernandez, Israel; Wegmann, Susanne; Hyman, Bradley T.; Gradinaru, Viviana; Kampmann, Martin; Kosik, Kenneth S. (April 2020). "LRP1 is a master regulator of tau uptake and spread". Nature. pp. 381–385. doi:10.1038/s41586-020-2156-5.
- ↑ Hayashi, Yasunori; Ford, Lenzie K.; Fioriti, Luana; McGurk, Leeanne; Zhang, Mingjie (3 February 2021). "Liquid-Liquid Phase Separation in Physiology and Pathophysiology of the Nervous System". Journal of Neuroscience. pp. 834–844. doi:10.1523/JNEUROSCI.1656-20.2020.
- ↑ Knowles, Roger B.; Sabry, James H.; Martone, Maryann E.; Deerinck, Thomas J.; Ellisman, Mark H.; Bassell, Gary J.; Kosik, Kenneth S. (15 December 1996). "Translocation of RNA Granules in Living Neurons". Journal of Neuroscience. pp. 7812–7820. doi:10.1523/JNEUROSCI.16-24-07812.1996.
- ↑ Xu, Na; Papagiannakopoulos, Thales; Pan, Guangjin; Thomson, James A.; Kosik, Kenneth S. (15 May 2009). "MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells". Cell. pp. 647–658. doi:10.1016/j.cell.2009.02.038.
- ↑ Lalli, Matthew A.; Jang, Jiwon; Park, Joo-Hye C.; Wang, Yidi; Guzman, Elmer; Zhou, Hongjun; Audouard, Morgane; Bridges, Daniel; Tovar, Kenneth R.; Papuc, Sorina M.; Tutulan-Cunita, Andreea C.; Huang, Yadong; Budisteanu, Magdalena; Arghir, Aurora; Kosik, Kenneth S. (1 April 2016). "Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways". Human Molecular Genetics. pp. 1294–1306. doi:10.1093/hmg/ddw010.
- ↑ Kosik, Kenneth S.; Donahue, Christine P.; Israely, Inbal; Liu, Xin; Ochiishi, Tomoyo (1 March 2005). "δ-Catenin at the synaptic–adherens junction". Trends in Cell Biology. pp. 172–178. doi:10.1016/j.tcb.2005.01.004.
- ↑ Bauer, Karl E.; Queiroz, Bruna R. de; Kiebler, Michael A.; Besse, Florence (1 July 2023). "RNA granules in neuronal plasticity and disease". Trends in Neurosciences. pp. 525–538. doi:10.1016/j.tins.2023.04.004.
Partly done: Reworded slightly Encoded Talk 💬 17:33, 21 December 2025 (UTC)
Addition of Biography section
edit | This edit request by an editor with a conflict of interest was declined. |
- What I think should be changed (include citations):
Biography section (new):
- Addition of biography section that summarizes education, positions, and appointments.
Updated version:
Kenneth Kosik completed a B.A. and M.A. in English literature from Case Western Reserve University in 1972 and an M.D. from the Medial College of Pennsylvania in 1976. He served as a resident in neurology at Tufts New England Medical Center and was Chief Resident in 1980. From 1980 to 2004, he held a series of academic appointments at the Harvard Medical School and achieved the rank of full professor there in 1996. Kosik also held appointments at McLean Hospital, Brigham and Women’s Hospital, the Massachusetts General Hospital and the Dana-Farber Cancer Institute between 1980 and 2004. In 2004, Kosik became the Harriman Professor of Neuroscience Research, where he also serves as Co-Director of the Neuroscience Research Institute at the University of California, Santa Barbara. Kosik also currently co-directs the Tau Consortium, co-founded the Learning and the Brain Conference, and has a longstanding interest in the interface between neuroscience and education [1].
- Why it should be changed:
- Addition of Biography section to summarize professional background.
NRI-gaucho (talk) 19:07, 20 October 2025 (UTC)
References
- ↑ "Kenneth Kosik, MD". John Douglas French Alzheimer's Foundation. 28 February 2020.
Not done for now: This content is almost word-for-word the same as the source, which may introduce copyright issues. Please re-write the section to help us avoid this. Many thanks, Encoded Talk 💬 17:29, 21 December 2025 (UTC)
- Would be great to have some more reliable sources as well! :) Encoded Talk 💬 17:30, 21 December 2025 (UTC)
Update to Awards section on Kenneth S. Kosik page
edit | This edit request by an editor with a conflict of interest has now been answered. |
- What I think should be changed (include citations):
Update to Awards section:
2021, Potamkin Prize[1] 2017, Elected American Association for the Advancement of Science Fellow[2] 2004, Harriman Chair in Neuroscience, University of California, Santa Barbara[3] 2002, Premio Aventis-Academia Nacionale de Medicina, Colombia[4] 1991, Zenith Award, Alzheimer Association[5] 1990, Derek Denny-Brown Neurological Scholar Award[6] 1988, Moore Award, American Association of Neuropathologists[7]
- Why it should be changed:
Inclusion of citations for Awards section.
NRI-gaucho (talk) 22:37, 30 March 2026 (UTC)
References
- ↑ "Past Recipients". The Potamkin Prize.
- ↑ "Elected Fellows". American Association for the Advancement of Science.
- ↑ "UC Santa Barbara General Catalog - Endowed Chairs". my.sa.ucsb.edu.
- ↑ "LLos premios de investigación en la Academia". Issuu.
- ↑ "Zenith Fellows - Alzheimer's Association". Alzheimer’s Association.
- ↑ "Derek Denny-Brown Young Neurological Scholar Award". ANA: American Neurological Association.
- ↑ "Awards and Lectures". www.neuropath.org.
Reply 26-MAY-2026
edit
Clarification requested
- By their very nature, awards can be subjective, in that they represent a very specific point of view — that of the individual or organization determining who wins the award and why. To counter this, a good practice is to limit the listing of awards to only those which are independently notable in Wikipedia.[a]
- To include a list of awards here, please ensure that only awards which are independently notable in Wikipedia are listed in the request.[b]
- When ready to proceed with the list of independently notable awards, kindly change the
{{Edit COI}}template's answer parameter to read from|ans=yto|ans=n. Please note that prior text entered in the Edit request proposal should not be retro-actively altered. Instead, a new reply post supplying the needed information should be posted below this review. The original{{Edit COI}}template may then be altered. Thank you!
Regards, Spintendo 14:00, 26 May 2026 (UTC)
Notes
- ↑ An award which is independently notable is recognized by having its own article in Wikipedia.
- ↑ The request for notability in this case is to ensure WP:NPOV. That's because adding several points of view to an article in the form of an awards section may skew the article's balance.[1] Thus, this reviewer's own practice is to limit the listing of awards to those which are independently notable in Wikipedia.
References
- ↑ "WP:BALANCE". Wikipedia. 20 July 2019.
...articles should not give minority views or aspects as much of or as detailed a description as more widely held views or widely supported aspects.
Edit Request: Removal of page errors
edit | The user below has a request that a significant addition or re-write be made to this article for which that user has an actual or apparent conflict of interest. The backlog is very high. Please be extremely patient. There are currently 534 requests waiting for review. Please read the instructions for the parameters used by this template for accepting and declining them, and review the request below and make the edit if it is well sourced, neutral, and follows other Wikipedia guidelines and policies. |
- What I think should be changed (include citations): Request for removal of Excessive Links warning and Biography of a Living Person References.
- Why it should be changed: Issues have been resolved.
NRI-gaucho (talk) 20:07, 23 June 2026 (UTC)
References