Talk:Huntington's disease
Latest comment: 5 months ago by Aeffenberger in topic Formatting of the mutant HTT shortening - consensus for change
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editPercentage of at-risk people who get genetic testing
editIt says that 5% of people choose to get tested, but the sources I've read say 10-20%. Could that be an old number? Wikipedia's Biggest Fan (talk) 18:22, 25 April 2025 (UTC)
Co-ordination required; or a merge
editThe sections Reducing huntingtin production and Clinical trials must be joined or at least aligned so that they proffer the same updated information, e.g. the development from the Uniqure trials. -The Gnome (talk) 22:04, 25 September 2025 (UTC)
Formatting of the mutant HTT shortening - consensus for change
edit | Consensus to change the abbreviation of huntingtin and mutant huntingtin to HTT and mHTT (from Htt and mHtt) in line with the majority of scientific articles on the topic. |
This article, and the article Huntingtin use the abbreviations Htt and mHtt for huntingtin and mutant huntingtin. However the vast majority of scientific and medical literature on the topic uses the abbreviation HTT and mHTT for huntingtin and mutant huntingtin.
The following articles support my claim.
- Roche: Huntington's Disease Pathology & Mechanisms of Disease
- Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease
- Mutant Huntingtin Drives Development of an Advantageous Brain Early in Life: Evidence in Support of Antagonistic Pleiotropy
- Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies
- TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
- Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation
There are many more but I'm not going to put these.
There are some articles that use htt and mhtt (all lower-case) and some that use Htt and mHtt. However these seem to be much less prevalent than HTT and mHTT. Book literature seems to be mostly equal in htt and Htt, while some forgo using any abbreviation. KarmaKangaroo (talk) 03:50, 2 November 2025 (UTC)
- Hi KarmaKangaroo -- you are absolutely correct, the human huntingtin gene/protein should be formatted as HTT or mHTT. Mouse proteins are written in sentence case and zebrafish genes are written in lowercase, and much research is done in animal models of HD, so I speculate that information sourced from such articles preserved those conventions. However, since the article is primarily concerned with the human disease, the all-caps version should almost always be used. I'll go through the article and correct this now. Aeffenberger (talk) 16:47, 20 January 2026 (UTC)