Talk:Adenylylation

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 11 February 2021 and 21 May 2021. Further details are available on the course page. Student editor(s): Allishaishaque17, Giangpham17.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 11:48, 18 January 2022 (UTC)

Incorrect statements in the article

The article is not bad as of 2026, but it contains a few, in my opinion, incorrect statements.

For instance, right now the following is stated:

"Plants and yeasts have no known endogenous AMPylating enzymes"

But I believe this is not correct with regard to yeasts. SelO (Selenoprotein O) is called a pseudokinase, but it is actually an ampylase, as shown in this article:

https://pmc.ncbi.nlm.nih.gov/articles/PMC6524645/

See: "Schematic representation of the SelO protein depicting the predicted mitochondrial targeting peptide (mTP) and kinase domain. The amino acid sequences at the C-terminus of the human, mouse, yeast and E. coli proteins are shown".

Now they also used another crystallized SelO protein for subsequent studies, but if you look at the article, they mention yeast several times with regards to SelO. Thus, if SelO is called an ampylase/AMPylator, then logically this is also found in yeast. Which means the wikipedia article is currently incorrect in this regard. ~2026-21970-63 (talk) 15:47, 23 April 2026 (UTC)

Edit: Also the link to yeast UniProt SelO: https://www.uniprot.org/uniprotkb/Q08968/entry

It is on yeast chromosome 16: https://www.uniprot.org/uniprotkb/Q08968/genomic-coordinates — Preceding unsigned comment added by ~2026-21970-63 (talk) 15:49, 23 April 2026 (UTC)