Semenogelin-2 is a protein that in humans is encoded by the SEMG2 gene .[ 3] [ 4] [ 5]
The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20.[ 5]
1 2 3 GRCh38: Ensembl release 89: ENSG00000124157 – Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ Ulvsback M, Lazure C, Lilja H, Spurr NK, Rao VV, Loffler C, Hansmann I, Lundwall A (Oct 1992). "Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20" . J Biol Chem . 267 (25): 18080– 4. doi :10.1016/S0021-9258(19)37155-8 PMID 1517240 . ↑ Peter A, Lilja H, Lundwall A, Malm J (Apr 1998). "Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase" . Eur J Biochem . 252 (2): 216– 21. doi :10.1046/j.1432-1327.1998.2520216.x PMID 9523691 . 1 2 "Entrez Gene: SEMG2 semenogelin II" .
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