Protein geranylgeranyltransferase type I

In enzymology, a protein geranylgeranyltransferase type I (EC 2.5.1.59) is an enzyme that catalyzes the chemical reaction

CAAX-protein geranylgeranyltransferase
Identifiers
EC no.	2.5.1.59
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

geranylgeranyl diphosphate + protein-cysteine $\rightleftharpoons$ S-geranylgeranyl-protein + diphosphate

Thus, the two substrates of this enzyme are geranylgeranyl diphosphate and protein-cysteine, whereas its two products are S-geranylgeranyl-protein and diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranylgeranyl-diphosphate:protein-cysteine geranyltransferase. Other names in common use include GGTase-I, and GGTaseI.

Structural studies

As of late 2007, 17 structures have been solved for this class of enzymes, with PDB accession codes 1S63, 1S64, 1SA4, 1SA5, 1TNB, 1TNO, 1TNU, 1TNY, 1TNZ, 1X81, 2BED, 2F0Y, 2H6F, 2H6G, 2H6H, 2H6I, and 2IEJ.

References

• Casey PJ, Seabra MC (1996). "Protein prenyltransferases". J. Biol. Chem. 271 (10): 5289–92. doi:10.1074/jbc.271.10.5289. PMID 8621375.
• Zhang FL, Casey PJ (1996). "Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I". Biochem. J. 320 (Pt 3): 925–32. doi:10.1042/bj3200925. PMC 1218017. PMID 9003382.
• Sinnott, M. (Ed.), Comprehensive Biological Catalysis. A Mechanistic Reference, vol. 1, Academic Press, San Diego, CA, 1998, p. 31-118.