Pinene synthase

In enzymology, a pinene synthase (EC 4.2.3.14) is an enzyme that catalyzes the chemical reaction

pinene synthase
Identifiers
EC no.	4.2.3.14
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

geranyl diphosphate $\rightleftharpoons$ pinene + diphosphate

Hence, this enzyme has one substrate, geranyl diphosphate, and two products, pinene and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is geranyl-diphosphate diphosphate-lyase (cyclizing, pinene-forming). Other names in common use include beta-geraniolene synthase, (−)-(1S,5S)-pinene synthase, and geranyldiphosphate diphosphate lyase (pinene forming). This enzyme participates in monoterpenoid biosynthesis.

References

• Bohlmann J, Steele CL, Croteau R (1997). "Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (−)-(4S)-limonene synthase, and (−)-(1S,5S)-pinene synthase". J. Biol. Chem. 272 (35): 21784–21792. doi:10.1074/jbc.272.35.21784. PMID 9268308.
• Gijzen M, Lewinsohn E, Croteau R (1991). "Characterization of the constitutive and wound-inducible monoterpene cyclases of grand fir (Abies grandis)". Arch. Biochem. Biophys. 289 (2): 267–273. doi:10.1016/0003-9861(91)90471-T. PMID 1898071.
• Wagschal KC, Pyun HJ, Coates RM, Croteau R (1994). "Monoterpene biosynthesis: isotope effects associated with bicyclic olefin formation catalyzed by pinene synthases from sage (Salvia officinalis)". Arch. Biochem. Biophys. 308 (2): 477–487. doi:10.1006/abbi.1994.1068. PMID 8109978.