Perfusion CT

Perfusion CT
Perfusion CT
	CT perfusion with flow and volume maps in cerebral infarction
Synonyms	CT Perfusion
Purpose	Perfusion Scanning using CT
Based on	Temporal changes in tissue attenuation after injection of Contrast

Perfusion CT (also CT Perfusion or CTP) is a form of perfusion scanning that uses computed tomography to assess the vascularity of tissues in the body.^[1] By measuring temporal changes in tissue attenuation following intravenous injection of an iodinated contrast agent CTP generates quantitative parametric maps of haemodynamic parameters including cerebral blood flow, mean transit time (MTT), and time to peak (TTP).^[2] These maps provide functional information about capillary-level blood supply that complements the anatomical information obtained from conventional CT.^[3]

Clinical use

Acute Ischemic Stroke

CT Perfusion plays an important role in the assessment of Acute Ischemic Stroke. It is used to create maps of blood flow, blood volume, and mean transit time to assess the tissue and to differentiate between the core and penumbra in stroke.^[4]

References

↑ Hoeffner, Ellen G.; Case, Ian; Jain, Rajan; Gujar, Sachin K.; Shah, Gaurang V.; Deveikis, John P.; Carlos, Ruth C.; Thompson, B. Gregory; Harrigan, Mark R.; Mukherji, Suresh K. (2004). "Cerebral Perfusion CT: Technique and Clinical Applications". Radiology. 231 (3): 632–644. doi:10.1148/radiol.2313021488. ISSN 0033-8419. PMID 15118110.
↑ Chung, Kevin J.; De Sarno, Danny; Lee, Ting-Yim (2023-12-19). "Quantitative functional imaging with CT perfusion: technical considerations, kinetic modeling, and applications". Frontiers in Physics. 11 1246973. Bibcode:2023FrP....1146973C. doi:10.3389/fphy.2023.1246973. ISSN 2296-424X.
↑ Konstas, A. A.; Goldmakher, G. V.; Lee, T.-Y.; Lev, M. H. (2009-04-01). "Theoretic Basis and Technical Implementations of CT Perfusion in Acute Ischemic Stroke, Part 1: Theoretic Basis". American Journal of Neuroradiology. 30 (4): 662–668. doi:10.3174/ajnr.A1487. ISSN 0195-6108. PMC 7051780. PMID 19270105.
↑ "Eckert B, Küsel T, Leppien a et al. Clinical outcome and imaging follow-up in acute stroke patients with normal perfusion CT and normal CT angiography. Neuroradiology 2011; 53: 79–88". Neuroradiologie Scan. 1 (1): 22–23. 2011-10-12. doi:10.1055/s-0030-1256919. ISSN 1616-9697. S2CID 260379976.

[1] Hoeffner, Ellen G.; Case, Ian; Jain, Rajan; Gujar, Sachin K.; Shah, Gaurang V.; Deveikis, John P.; Carlos, Ruth C.; Thompson, B. Gregory; Harrigan, Mark R.; Mukherji, Suresh K. (2004). "Cerebral Perfusion CT: Technique and Clinical Applications". Radiology. 231 (3): 632–644. doi:10.1148/radiol.2313021488. ISSN 0033-8419. PMID 15118110.

[2] Chung, Kevin J.; De Sarno, Danny; Lee, Ting-Yim (2023-12-19). "Quantitative functional imaging with CT perfusion: technical considerations, kinetic modeling, and applications". Frontiers in Physics. 11 1246973. Bibcode:2023FrP....1146973C. doi:10.3389/fphy.2023.1246973. ISSN 2296-424X.

[3] Konstas, A. A.; Goldmakher, G. V.; Lee, T.-Y.; Lev, M. H. (2009-04-01). "Theoretic Basis and Technical Implementations of CT Perfusion in Acute Ischemic Stroke, Part 1: Theoretic Basis". American Journal of Neuroradiology. 30 (4): 662–668. doi:10.3174/ajnr.A1487. ISSN 0195-6108. PMC 7051780. PMID 19270105.

[4] "Eckert B, Küsel T, Leppien a et al. Clinical outcome and imaging follow-up in acute stroke patients with normal perfusion CT and normal CT angiography. Neuroradiology 2011; 53: 79–88". Neuroradiologie Scan. 1 (1): 22–23. 2011-10-12. doi:10.1055/s-0030-1256919. ISSN 1616-9697. S2CID 260379976.

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