PRB1

Basic salivary proline-rich protein 1 is a protein that in humans is encoded by the PRB1 gene.

PRB1
Identifiers
Aliases	PRB1, PM, PMF, PMS, PRB1L, PRB1M, proline rich protein BstNI subfamily 1, proline rich protein BstNI subfamily 1 (gene/pseudogene)
External IDs	OMIM: 180989; MGI: 1924007; GeneCards: PRB1; OMA:PRB1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.2 Start 11,351,823 bp End 11,355,591 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 A4 Start 32,956,550 bp End 33,352,705 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa tonsil bone marrow sural nerve bone marrow cell putamen caudate nucleus nucleus accumbens skin of leg superior frontal gyrus Top expressed in ankle triceps brachii muscle muscle of thigh extraocular muscle temporal muscle sternocleidomastoid muscle interventricular septum vastus lateralis muscle tibialis anterior muscle digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular function Cellular component extracellular region Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5542 76757 Ensembl ENSG00000251655 ENSMUSG00000019787 UniProt P04280 E9Q9K5 RefSeq (mRNA) NM_199354 NM_005039 NM_199353 NM_001367912 NM_029726 NM_001364696 NM_001364697 RefSeq (protein) NP_005030 NP_001354841 NP_084002 NP_001351625 NP_001351626 Location (UCSC) Chr 12: 11.35 – 11.36 Mb Chr 10: 32.96 – 33.35 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Further reading

• Azen EA, Maeda N (1988). "Molecular Genetics of Human Salivary Proteins and Their Polymorphisms". Advances in Human Genetics 1. Vol. 17. pp. 141–99. doi:10.1007/978-1-4613-0987-1_5. ISBN 978-1-4612-8279-2. PMID 3055850.
• Bennick A (1982). "Salivary proline-rich proteins". Mol. Cell. Biochem. 45 (2): 83–99. doi:10.1007/BF00223503. PMID 6810092. S2CID 31373141.
• Ikemoto S, Minaguchi K, Suzuki K, Tomita K (1977). "New Genetic marker in human parotid saliva (pm)". Science. 197 (4301): 378–9. Bibcode:1977Sci...197..378I. doi:10.1126/science.877561. PMID 877561.
• Castle AM, Stahl LE, Castle JD (1992). "A 13-amino acid n-terminal domain of a basic proline-rich protein is necessary for storage in secretory granules and facilitates exit from the endoplasmic reticulum". J. Biol. Chem. 267 (18): 13093–100. doi:10.1016/S0021-9258(18)42385-X. PMID 1618808.
• Lyons KM, Stein JH, Smithies O (1989). "Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over". Genetics. 120 (1): 267–78. doi:10.1093/genetics/120.1.267. PMC 1203497. PMID 2851479.
• Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. doi:10.1016/S0021-9258(17)39156-1. PMID 2993301.
• Kauffman D, Hofmann T, Bennick A, Keller P (1986). "Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6". Biochemistry. 25 (9): 2387–92. doi:10.1021/bi00357a013. PMID 3521730.
• Azen E, Lyons KM, McGonigal T, et al. (1984). "Clones from the human gene complex coding for salivary proline-rich proteins". Proc. Natl. Acad. Sci. U.S.A. 81 (17): 5561–5. Bibcode:1984PNAS...81.5561A. doi:10.1073/pnas.81.17.5561. PMC 391746. PMID 6089212.
• Saitoh E, Isemura S, Sanada K (1984). "Further fractionation of basic proline-rich peptides from human parotid saliva and complete amino acid sequence of basic proline-rich peptide P-H". J. Biochem. 94 (6): 1991–9. doi:10.1093/oxfordjournals.jbchem.a134553. PMID 6671974.
• Kauffman D, Wong R, Bennick A, Keller P (1983). "Basic proline-rich proteins from human parotid saliva: complete covalent structure of protein IB-9 and partial structure of protein IB-6, members of a polymorphic pair". Biochemistry. 21 (25): 6558–62. doi:10.1021/bi00268a036. PMID 6924859.
• Isemura S, Saitoh E, Sanada K (1982). "Fractionation and characterization of basic proline-rich peptides of human parotid saliva and the amino acid sequence of proline-rich peptide P-E". J. Biochem. 91 (6): 2067–75. doi:10.1093/oxfordjournals.jbchem.a133900. PMID 7118863.
• Kim HS, Lyons KM, Saitoh E, et al. (1993). "The structure and evolution of the human salivary proline-rich protein gene family". Mamm. Genome. 4 (1): 3–14. doi:10.1007/BF00364656. PMID 8422499. S2CID 24058984.
• Castle AM, Castle JD (1998). "Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein". Mol. Biol. Cell. 9 (3): 575–83. doi:10.1091/mbc.9.3.575. PMC 25286. PMID 9487127.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
• Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases". Eur. J. Biochem. 268 (12): 3423–31. doi:10.1046/j.1432-1327.2001.02241.x. PMID 11422372.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.