Neuroserpin is a protein that in humans is encoded by the SERPINI1 gene .[ 5]
It is associated with Familial encephalopathy with neuroserpin inclusion bodies .
Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons (Stoeckli et al., 1989). It is expressed in the late stages of neurogenesis during the process of synapse formation.[supplied by OMIM][ 5]
1 2 3 GRCh38: Ensembl release 89: ENSG00000163536 – Ensembl , May 20171 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027834 – Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .1 2 "Entrez Gene: SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1" .↑ Parmar PK, Coates Leigh C, Pearson John F, Hill Rena M, Birch Nigel P (September 2002). "Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells". J. Neurochem . 82 (6): 1406– 15. doi :10.1046/j.1471-4159.2002.01100.x . ISSN 0022-3042 . PMID 12354288 . S2CID 23571680 .
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