NPW

This article is about a human gene. For net present worth, see Net present value.

NPW is a gene that in humans encodes Neuropeptide W protein.

NPW
Identifiers
Aliases	NPW, L8, L8C, PPL8, PPneuropeptide W
External IDs	OMIM: 607997; MGI: 2685781; HomoloGene: 17727; GeneCards: NPW; OMA:NPW - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p13.3 Start 2,009,926 bp End 2,020,755 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 A3.3 Start 24,876,304 bp End 24,877,431 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle decidua right lobe of liver gonad stromal cell of endometrium pituitary gland anterior pituitary olfactory zone of nasal mucosa skin of abdomen skin of leg Top expressed in embryo lung embryo morula epiblast stomach uterus pancreas spleen superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding G protein-coupled receptor binding Cellular component extracellular region Biological process neuropeptide signaling pathway feeding behavior G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 283869 381073 Ensembl ENSG00000183971 ENSMUSG00000071230 UniProt Q8N729 Q3V2F0 RefSeq (mRNA) NM_001099456 NM_001099664 RefSeq (protein) NP_001092926 NP_001093134 Location (UCSC) Chr 16: 2.01 – 2.02 Mb Chr 17: 24.88 – 24.88 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Neuropeptide W (NPW) is an endogenous peptide ligand for GPR8 (MIM 600731), a G protein-coupled receptor.[supplied by OMIM]

Further reading

• Singh G, Davenport AP (2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". Br. J. Pharmacol. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Shimomura Y, Harada M, Goto M, et al. (2002). "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 277 (39): 35826–32. doi:10.1074/jbc.M205337200. PMID 12130646.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tanaka H, Yoshida T, Miyamoto N, et al. (2003). "Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6. Bibcode:2003PNAS..100.6251T. doi:10.1073/pnas.0837789100. PMC 156358. PMID 12719537.
• Mondal MS, Yamaguchi H, Date Y, et al. (2003). "A role for neuropeptide W in the regulation of feeding behavior". Endocrinology. 144 (11): 4729–33. doi:10.1210/en.2003-0536. PMID 12959997.
• Mazzocchi G, Rebuffat P, Ziolkowska A, et al. (2005). "G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades". J. Clin. Endocrinol. Metab. 90 (6): 3466–71. doi:10.1210/jc.2004-2132. PMID 15797961.
• Andreis PG, Rucinski M, Neri G, et al. (2006). "Neuropeptides B and W enhance the growth of human adrenocortical carcinoma-derived NCI-H295 cells by exerting MAPK p42/p44-mediated proliferogenic and antiapoptotic effects". Int. J. Mol. Med. 16 (6): 1021–8. doi:10.3892/ijmm.16.6.1021. PMID 16273281.
• Mondal MS, Yamaguchi H, Date Y, et al. (2006). "Neuropeptide W is present in antral G cells of rat, mouse, and human stomach". J. Endocrinol. 188 (1): 49–57. doi:10.1677/joe.1.06195. PMID 16394174.