NMRA-511, also known as BTRX-323511 or NMRA-323511, is a vasopressin V1A receptor antagonist which is under development for the treatment of agitation and anxiety disorders.[1][2][3][4] It has been found to reduce threat behaviors in marmosets.[4] The drug was originated by BlackThorn Therapeutics and is under development by Neumora Therapeutics.[1][2][3] As of April 2026, it is in phase 1 clinical trials for agitation, whereas no decent development has been reported for anxiety disorders.[1] The chemical structure of NMRA-511 does not yet appear to have been disclosed.[1][3]
| Clinical data | |
|---|---|
| Other names | NMRA511; BTRX-323511; BTRX323511; NMRA-323511; NMRA323511 |
| Drug class | Vasopressin V1A receptor antagonist |
See also
editReferences
edit- 1 2 3 4 "NMRA 511". AdisInsight. 10 April 2026. Retrieved 2 June 2026.
- 1 2 "Delving into the Latest Updates on NMRA-511 with Synapse". Synapse. 19 March 2026. Retrieved 2 June 2026.
- 1 2 3 Baska F, Bozó É, Patócs T (2023). "Vasopressin receptor antagonists: a patent summary (2018-2022)". Expert Opinion on Therapeutic Patents. 33 (5): 385–395. doi:10.1080/13543776.2023.2218546. PMID 37226495.
BlackThorn Therapeutics has also investigated selective V1a receptor antagonists for the treatment of social and emotional disabilities. They prioritized the scaffold hopping approach during their research and modified the well-known benzodiazepine and benzazepine structures [61–63]. These attempts resulted in BTRX-323511, but after the merge with Neumora Therapeutics, the compound was further developed as NMRA511 (its structure has not yet been disclosed) [97].
- 1 2 Wallace, T., Morrison, F., Gerrard, P., Ereshefsky, L., Ballard, M., Posener, J., ... & Tiller, J (December 2022). "NMRA-511, a Novel Vasopressin 1a (V1a) Receptor Antagonist Reduces Threat Behaviors in Marmosets and Alters EEG Power Spectra Similarly in Marmosets and Humans". Neuropsychopharmacology. 47 (Suppl 1): 334.
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