Methyl-ONN-azoxymethanol beta-D-glucosyltransferase (EC 2.4.1.171) is an enzyme that catalyzes the chemical reaction
| Methyl-ONN-azoxymethanol beta-D-glucosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.171 | ||||||||
| CAS no. | 99283-65-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The two substrates of this enzyme characterised from Cycas revoluta are methylazoxymethanol acetate (MAM) and UDP-glucose. Its products are the neurotoxic glucoside, cycasin,[1] and uridine diphosphate (UDP).[2]
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:methyl-ONN-azoxymethanol beta-D-glucosyltransferase. Other names in common use include cycasin synthase, uridine diphosphoglucose-methylazoxymethanol glucosyltransferase, and UDP-glucose-methylazoxymethanol glucosyltransferase.[3]
References
edit- ↑ Moretti, A.; Sabato, S.; Gigliano, G.Siniscalco (January 1983). "Taxonomic significance of methylazoxymethanol glycosides in the cycads". Phytochemistry. 22 (1): 115–117. Bibcode:1983PChem..22..115M. doi:10.1016/S0031-9422(00)80069-2.
- ↑ Tadera K, Yagi F, Arima M, Kobayashi A (1985). "Formation of cycasin from methylazoxymethanol by UDP-glucosyltransferase from leaves of Japanese cycad". Agric. Biol. Chem. 49 (9): 2827–2828. doi:10.1271/bbb1961.49.2827.
- ↑ Enzyme 2.4.1.171 at KEGG Pathway Database.
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