In enzymology, mannitol 2-dehydrogenase (NADP+) (EC 1.1.1.138) is an enzyme that catalyzes the chemical reaction
| mannitol 2-dehydrogenase (NADP+) | |||||||||
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| Identifiers | |||||||||
| EC no. | 1.1.1.138 | ||||||||
| CAS no. | 37250-68-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The two substrates of this enzyme are D-mannitol and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are D-fructose (shown in its open-chain form), reduced NADPH, and a proton.[1][2][3]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-mannitol:NADP+ 2-oxidoreductase. This enzyme is also called mannitol 2-dehydrogenase (NADP+). This enzyme participates in fructose and mannose metabolism.
Structural studies
editReferences
edit- ↑ Enzyme 1.1.1.138 at KEGG Pathway Database.
- ↑ Edmundowicz JM, Wriston JC (1963). "Mannitol dehydrogenase from Agaricus campestris". J. Biol. Chem. 238 (11): 3539–41. doi:10.1016/S0021-9258(19)75304-6. PMID 14109183.
- ↑ Strobel GA; Kosuge T (1965). "Polyol metabolism in Diplodia viticola Desm". Arch. Biochem. Biophys. 109 (3): 622–626. doi:10.1016/0003-9861(65)90409-1. PMID 14320506.
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