MAG1 is a gene in the yeast Saccharomyces cerevisiae that encodes DNA-3-methyladenine glycosylase, a monofunctional DNA N-glycosylase involved in base excision repair.[1][2][3] It initiates repair of alkylation damage and helps protect yeast cells from methylating agents.[2]

3-methyl-adenine DNA glycosylase
[Saccharomyces cerevisiae]
Identifiers
SymbolMAG1
NCBI gene856885
UniProtP22134
Other data
EC number3.2.2.21
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StructuresSwiss-model
DomainsInterPro

Function

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MAG1 transcription is induced when yeast cells are exposed to relatively non-toxic levels of alkylating agents.[4] The encoded glycosylase has been reported to excise 3-methyladenine, 7-methylguanine, hypoxanthine, and 1,N6-ethenoadenine from DNA.[3]

References

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