In enzymology, lactaldehyde reductase (EC 1.1.1.77) is an enzyme that catalyzes two chemical reactions
| lactaldehyde reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.77 | ||||||||
| CAS no. | 37250-15-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
-1,2-Propanediol.svg)
-Lactaldehyde.svg)
-1,2-Propanediol.svg)
-Lactaldehyde.svg)
Each individual reaction is stereospecific so that when the substrate of the enzyme is (R)-propane-1,2-diol it produces (R)-lactaldehyde but the enantiomeric substrate (S)-propane-1,2-diol gives only (S)-lactaldehyde. The enzyme's cofactor is nicotinamide adenine dinucleotide (NAD+), which is converted to NADH, and also releases a proton.[1][2]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)[or (S)]-propane-1,2-diol:NAD+ oxidoreductase. Other names in common use include propanediol:nicotinamide adenine dinucleotide (NAD+) oxidoreductase, and L-lactaldehyde:propanediol oxidoreductase. This enzyme participates in pyruvate metabolism and glyoxylate and dicarboxylate metabolism.
Structural studies
editAs of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1RRM, 2BI4, and 2BL4.
References
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