Katherine Anne Henzler-Wildman is the Jean V. Thomas Professor in Biochemistry at the University of Wisconsin–Madison. She was elected a fellow of the American Association for the Advancement of Science in 2024. She is known for her work on how proteins control the movement of molecules across membranes.
Katherine Henzler-Wildman | |
|---|---|
| Alma mater | University of Michigan |
| Scientific career | |
| Thesis | The mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37 (2003) |
Education and career
editHenzler-Wildman received a B.A. from Cornell University in 1998.[1] She earned her Ph.D. from the University of Michigan in 2003.[2] She then moved to Brandeis University where she worked with Dorothee Kern as a postdoctoral researcher until 2008 when she joined the faculty at Washington University in St. Louis.[2] In 2015 moved to the University of Madison, and as of 2025 Henzler-Wildman is the Jean V. Thomas Professor in Biochemistry.[3]
Research
editHenzler-Wildman's early research determined structural details of lipid membranes[4] and the dynamics of protein folding.[5] She has investigated the protein EmrE[6] and demonstrated how this protein pushes toxic molecules out of microbial cells.[7]
Selected publications
edit- Henzler-Wildman, Katherine; Kern, Dorothee (2007-12-13). "Dynamic personalities of proteins". Nature. 450 (7172): 964–972. doi:10.1038/nature06522. ISSN 0028-0836.
- Henzler-Wildman, Katherine A.; Lei, Ming; Thai, Vu; Kerns, S. Jordan; Karplus, Martin; Kern, Dorothee (2007). "A hierarchy of timescales in protein dynamics is linked to enzyme catalysis". Nature. 450 (7171): 913–916. doi:10.1038/nature06407. ISSN 0028-0836.
- Henzler Wildman, Katherine A.; Lee, Dong-Kuk; Ramamoorthy, A. (2003-06-01). "Mechanism of Lipid Bilayer Disruption by the Human Antimicrobial Peptide, LL-37". Biochemistry. 42 (21): 6545–6558. doi:10.1021/bi0273563. ISSN 0006-2960.
- Morrison, Emma A.; DeKoster, Gregory T.; Dutta, Supratik; Vafabakhsh, Reza; Clarkson, Michael W.; Bahl, Arjun; Kern, Dorothee; Ha, Taekjip; Henzler-Wildman, Katherine A. (2012). "Antiparallel EmrE exports drugs by exchanging between asymmetric structures". Nature. 481 (7379): 45–50. doi:10.1038/nature10703. ISSN 0028-0836. PMC 3253143. PMID 22178925.
- Lewis, Adam; Kurauskas, Vilius; Tonelli, Marco; Henzler-Wildman, Katherine (2021-10-28). "Ion-dependent structure, dynamics, and allosteric coupling in a non-selective cation channel". Nature Communications. 12 (1) 6225. doi:10.1038/s41467-021-26538-8. ISSN 2041-1723. PMC 8553846. PMID 34711838.
Awards and honors
editHenzler-Wildman was named a Searle Scholars Program in 2010,[8] and received the Margaret Oakley Dayhoff Award from the Biophysical Society in 2013.[9] She was elected a fellow of the American Association for the Advancement of Science in 2024.[10]
References
edit- ↑ Gordon, Sharona E. (2015-01-26). "To better serve our community: Introducing new Associate Editors and an expanded Editorial Advisory Board for 2015". Journal of General Physiology. 145 (2): 83–90. doi:10.1085/jgp.201411352. ISSN 0022-1295. PMC 4306714. PMID 25624446.
- 1 2 "Katherine A. Henzler-Wildman, PhD". Washington University Medicine. Retrieved 2025-04-19.
- ↑ "Henzler-Wildman, Katherine". Department of Biochemistry at the University of Wisconsin-Madison. 2019-09-19. Retrieved 2025-04-19.
- ↑ Henzler Wildman, Katherine A.; Lee, Dong-Kuk; Ramamoorthy, A. (2003-06-01). "Mechanism of Lipid Bilayer Disruption by the Human Antimicrobial Peptide, LL-37". Biochemistry. 42 (21): 6545–6558. doi:10.1021/bi0273563. ISSN 0006-2960.
- ↑ Henzler-Wildman, Katherine A.; Thai, Vu; Lei, Ming; Ott, Maria; Wolf-Watz, Magnus; Fenn, Tim; Pozharski, Ed; Wilson, Mark A.; Petsko, Gregory A.; Karplus, Martin; Hübner, Christian G.; Kern, Dorothee (2007). "Intrinsic motions along an enzymatic reaction trajectory". Nature. 450 (7171): 838–844. doi:10.1038/nature06410. ISSN 0028-0836.
- ↑ Morrison, Emma A.; DeKoster, Gregory T.; Dutta, Supratik; Vafabakhsh, Reza; Clarkson, Michael W.; Bahl, Arjun; Kern, Dorothee; Ha, Taekjip; Henzler-Wildman, Katherine A. (2012). "Antiparallel EmrE exports drugs by exchanging between asymmetric structures". Nature. 481 (7379): 45–50. doi:10.1038/nature10703. ISSN 0028-0836. PMC 3253143. PMID 22178925.
- ↑ Trafton, Anne (2022-02-25). "MIT Chemists Discover Structure of Protein That Pumps Toxic Molecules Out of Bacterial Cells". SciTechDaily. Retrieved 2025-04-19.
- ↑ Ericson, Gwen (2010-05-06). "Washington University biochemist named 2010 Searle Scholar". The Source. Retrieved 2025-04-19.
- ↑ "Biophysical Society Names Six 2013 Award Recipients" (PDF). Archived from the original (PDF) on 2018-03-16.
- ↑ "2024 AAAS Fellows | American Association for the Advancement of Science (AAAS)". www.aaas.org. Retrieved 2025-04-19.
External links
edit- Katherine Henzler-Wildman publications indexed by Google Scholar