Insulin-like growth factor 2 mRNA-binding protein 3 is a protein that in humans is encoded by the IGF2BP3 gene .[ 5] [ 6] [ 7]
The protein encoded by this gene is primarily found in the nucleolus , where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development.
The encoded protein contains several KH domains , which are important in RNA binding and are known to be involved in RNA synthesis and metabolism . A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.[ 7]
1 2 3 GRCh38: Ensembl release 89: ENSG00000136231 – Ensembl , May 20171 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029814 – Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development" . Mol Cell Biol . 19 (2): 1262– 70. doi :10.1128/MCB.19.2.1262 . PMC 116055 PMID 9891060 . ↑ Mueller-Pillasch F, Lacher U, Wallrapp C, Micha A, Zimmerhackl F, Hameister H, Varga G, Friess H, Buchler M, Beger HG, Vila MR, Adler G, Gress TM (Jul 1997). "Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein". Oncogene . 14 (22): 2729– 33. doi :10.1038/sj.onc.1201110 . PMID 9178771 . S2CID 838180 . 1 2 "Entrez Gene: IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3" .
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