Glycosylphosphatidylinositol phospholipase D (EC 3.1.4.50, GPI-PLD, glycoprotein phospholipase D, phosphatidylinositol phospholipase D, phosphatidylinositol-specific phospholipase D) is an enzyme with systematic name glycoprotein-phosphatidylinositol phosphatidohydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction
| Glycosylphosphatidylinositol phospholipase D | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.4.50 | ||||||||
| CAS no. | 113756-14-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myoinositol + H2O 6-(α-D-glucosaminyl)-1D-myo-inositol + 3-sn-phosphatidate
This enzyme cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors.
See also
editReferences
edit- ↑ Low MG, Prasad AR (February 1988). "A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma". Proceedings of the National Academy of Sciences of the United States of America. 85 (4): 980–4. Bibcode:1988PNAS...85..980L. doi:10.1073/pnas.85.4.980. PMC 279684. PMID 3422494.
- ↑ Malik AS, Low MG (December 1986). "Conversion of human placental alkaline phosphatase from a high Mr form to a low Mr form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases". The Biochemical Journal. 240 (2): 519–27. doi:10.1042/bj2400519. PMC 1147446. PMID 3028377.
- ↑ Li JY, Hollfelder K, Huang KS, Low MG (November 1994). "Structural features of GPI-specific phospholipase D revealed by proteolytic fragmentation and Ca2+ binding studies". The Journal of Biological Chemistry. 269 (46): 28963–71. doi:10.1016/S0021-9258(19)62000-4. PMID 7961859.
- ↑ Deeg MA, Bierman EL, Cheung MC (March 2001). "GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex". Journal of Lipid Research. 42 (3): 442–51. doi:10.1016/S0022-2275(20)31669-2. PMID 11254757.
External links
edit- Glycosylphosphatidylinositol+phospholipase+D at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
