Fringe gene

Available protein structures:
PDB	IPR017374
AlphaFold	IPR017374;

Fringe
Fringe
Identifiers
Symbol	FNG
InterPro	IPR017374
Membranome	1299
PDB
Available protein structures:
PDB	IPR017374
AlphaFold	IPR017374;

Fringe genes are important in the workings of the notch signaling pathway.^[1]

In Drosophila melanogaster (the fruit fly) the fringe gene (fng) was identified as part of the notch mechanism by Dr. Kenneth Irvine at the Waksman Institute at Rutgers.^{[citation needed]} Later based on similarity, the manic fringe (MFNG), the radical fringe (RFNG) and lunatic fringe (LFNG)^[2]^[3] genes were identified in mammals.

Fringe genes encode O-fucose specific β-1,3-N-Acetylglucosaminyltransferases (GlcNAcT) glycosyltransferases.

The gene products of radical fringe stimulate the Apical Ectodermal Ridge in limb-bud formation.

The mouse and human Fringe family members map to three different chromosomes:

Mfng maps to mouse Chr 15 and to human Chr 22.
Lfng maps to mouse Chr 5 and human Chr 7.
Rfng maps to mouse Chr 11 and human Chr 17.

References

↑ Gazave E, Lapébie P, Richards GS, Brunet F, Ereskovsky AV, Degnan BM, et al. (October 2009). "Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes". BMC Evolutionary Biology. 9 (1): 249. Bibcode:2009BMCEE...9..249G. doi:10.1186/1471-2148-9-249. PMC 2770060. PMID 19825158.
↑ Hopkin M (6 November 2006). "Troublesome gene names get the boot". Nature. doi:10.1038/news061106-2. S2CID 86514270.
↑ White M (26 September 2014). "Sonic Hedgehog, Dicer, and the Problem With Naming Genes". Pacific Standard. The Social Justice Foundation.

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[1] Gazave E, Lapébie P, Richards GS, Brunet F, Ereskovsky AV, Degnan BM, et al. (October 2009). "Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes". BMC Evolutionary Biology. 9 (1): 249. Bibcode:2009BMCEE...9..249G. doi:10.1186/1471-2148-9-249. PMC 2770060. PMID 19825158.

[2] Hopkin M (6 November 2006). "Troublesome gene names get the boot". Nature. doi:10.1038/news061106-2. S2CID 86514270.

[3] White M (26 September 2014). "Sonic Hedgehog, Dicer, and the Problem With Naming Genes". Pacific Standard. The Social Justice Foundation.

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