FG-5893

FG-5893
Clinical data
Other names	FG5893
Identifiers
	IUPAC name methyl 2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]pyridine-3-carboxylate;
CAS Number	150527-23-4;
PubChem CID	127728;
IUPHAR/BPS	13;
ChemSpider	113304;
UNII	2QR7EI62WQ;
CompTox Dashboard (EPA)	DTXSID50164565 ;
Chemical and physical data
Formula	C27H29F2N3O3
Molar mass	481.544 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC(=O)C1=C(N=CC=C1)N2CCN(CC2)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F;
	InChI InChI=1S/C27H29F2N3O2/c1-34-27(33)25-4-2-14-30-26(25)32-18-16-31(17-19-32)15-3-5-24(20-6-10-22(28)11-7-20)21-8-12-23(29)13-9-21/h2,4,6-14,24H,3,5,15-19H2,1H3; Key:NDCPNKXUTJGQQC-UHFFFAOYSA-N;

FG-5893 is a chemical from the diphenylbutylpiperazine class of agents. It is a 5-HT1A agonist and a 5-HT2A antagonist.^[1]

It is believed to be an anxiolytic agent with potential uses in the treatment of substance abuse disorders particularly alcoholism.^[2]^[3]^[4]

There is evidence for FG-5893 behaving as a SNDRI:^[5]

CNS review:^[6]

References

↑ Myers RD (1994). "New drugs for the treatment of experimental alcoholism". review. Alcohol. 11 (6). Fayetteville, N.Y.: 439–451. doi:10.1016/0741-8329(94)90064-7. PMID 7865140.
↑ Albinsson A, Björk A, Svartengren J, Klint T, Andersson G (August 1994). "Preclinical pharmacology of FG5893: a potential anxiolytic drug with high affinity for both 5-HT1A and 5-HT2A receptors". European Journal of Pharmacology. 261 (3): 285–94. doi:10.1016/0014-2999(94)90119-8. PMID 7813550.
↑ Lankford MF, Björk AK, Myers RD (1996). "Differential efficacy of serotonergic drugs FG5974, FG5893, and amperozide in reducing alcohol drinking in P rats". Alcohol (Fayetteville, N.Y.). 13 (4): 399–404. doi:10.1016/0741-8329(96)00061-4. PMID 8836330.
↑ Long TA, Kalmus GW, Björk A, Myers RD (January 1996). "Alcohol intake in high alcohol drinking (HAD) rats is suppressed by FG5865, a novel 5-HT1A agonist/5-HT2 antagonist". Pharmacology, Biochemistry, and Behavior. 53 (1): 33–40. doi:10.1016/0091-3057(95)00195-6. PMID 8848457.
↑ Pettersson, E. (August 1995). "Studies of four novel diphenylbutylpiperazinepyridyl derivatives on release and inhibition of reuptake of dopamine, serotonin and noradrenaline by rat brain in vitro". European Journal of Pharmacology. 282 (1–3): 131–135. doi:10.1016/0014-2999(95)00300-A. PMID 7498267.
↑ Andersson, G.; Albinsson, A.; Björk, A.; Svartengren, J. (December 1996). "FG5893: A Potential New Generation Anxiolytic/Antidepressant Drug with High Affinity for 5-HT 1A and 5-HT 2A Receptors". CNS Drug Reviews. 2 (4): 363–383. doi:10.1111/j.1527-3458.1996.tb00307.x.

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[Myers_1994-1] Myers RD (1994). "New drugs for the treatment of experimental alcoholism". review. Alcohol. 11 (6). Fayetteville, N.Y.: 439–451. doi:10.1016/0741-8329(94)90064-7. PMID 7865140.

[Albinsson_1994-2] Albinsson A, Björk A, Svartengren J, Klint T, Andersson G (August 1994). "Preclinical pharmacology of FG5893: a potential anxiolytic drug with high affinity for both 5-HT1A and 5-HT2A receptors". European Journal of Pharmacology. 261 (3): 285–94. doi:10.1016/0014-2999(94)90119-8. PMID 7813550.

[Lankford_1996-3] Lankford MF, Björk AK, Myers RD (1996). "Differential efficacy of serotonergic drugs FG5974, FG5893, and amperozide in reducing alcohol drinking in P rats". Alcohol (Fayetteville, N.Y.). 13 (4): 399–404. doi:10.1016/0741-8329(96)00061-4. PMID 8836330.

[Long_1996-4] Long TA, Kalmus GW, Björk A, Myers RD (January 1996). "Alcohol intake in high alcohol drinking (HAD) rats is suppressed by FG5865, a novel 5-HT1A agonist/5-HT2 antagonist". Pharmacology, Biochemistry, and Behavior. 53 (1): 33–40. doi:10.1016/0091-3057(95)00195-6. PMID 8848457.

[5] Pettersson, E. (August 1995). "Studies of four novel diphenylbutylpiperazinepyridyl derivatives on release and inhibition of reuptake of dopamine, serotonin and noradrenaline by rat brain in vitro". European Journal of Pharmacology. 282 (1–3): 131–135. doi:10.1016/0014-2999(95)00300-A. PMID 7498267.

[6] Andersson, G.; Albinsson, A.; Björk, A.; Svartengren, J. (December 1996). "FG5893: A Potential New Generation Anxiolytic/Antidepressant Drug with High Affinity for 5-HT 1A and 5-HT 2A Receptors". CNS Drug Reviews. 2 (4): 363–383. doi:10.1111/j.1527-3458.1996.tb00307.x.

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[2]

[3]

[4]

[5]

[6]

FG-5893

See also

References