ELF1

E74-like factor 1 (ets domain transcription factor) is a protein that in humans is encoded by the ELF1 gene. It was named for its similarity to E74, an ecdysone-inducible transcription factor from Drosophila.

ELF1
Identifiers
Aliases	ELF1, E74 like ETS transcription factor 1, EFTUD1, RIA1
External IDs	OMIM: 189973; MGI: 107180; HomoloGene: 7303; GeneCards: ELF1; OMA:ELF1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q14.11 Start 40,931,924 bp End 41,061,440 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 D3 Start 79,718,634 bp End 79,819,934 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte monocyte lymph node bone marrow cell Achilles tendon nipple appendix gallbladder mucosa of pharynx urethra Top expressed in mesenteric lymph nodes decidua thymus mucosa of urinary bladder transitional epithelium of urinary bladder blood left colon spleen lumbar spinal ganglion left lung lobe More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process regulation of cytokine production positive regulation of transcription, DNA-templated cell differentiation regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of T cell receptor signaling pathway transcription by RNA polymerase II regulation of cytokine-mediated signaling pathway regulation of B cell receptor signaling pathway regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1997 13709 Ensembl ENSG00000120690 ENSMUSG00000036461 UniProt P32519 Q60775 RefSeq (mRNA) NM_001145353 NM_172373 NM_001370329 NM_001370330 NM_001370331 NM_001370332 NM_001286411 NM_001286412 NM_007920 RefSeq (protein) NP_001138825 NP_758961 NP_001357258 NP_001357259 NP_001357260 NP_001357261 NP_001273340 NP_001273341 NP_031946 Location (UCSC) Chr 13: 40.93 – 41.06 Mb Chr 14: 79.72 – 79.82 Mb PubMed search
Wikidata
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Function

This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and can act as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants.

Further reading

• Xiang P, Lo C, Argiropoulos B, Lai CB, Rouhi A, Imren S, Jiang X, Mager D, Humphries RK (Sep 2010). "Identification of E74-like factor 1 (ELF1) as a transcriptional regulator of the Hox cofactor MEIS1". Experimental Hematology. 38 (9): 798–8, 808.e1-2. doi:10.1016/j.exphem.2010.06.006. PMC 3887005. PMID 20600580.
• Juang YT, Solomou EE, Rellahan B, Tsokos GC (Mar 2002). "Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR zeta-chain". Journal of Immunology. 168 (6): 2865–71. doi:10.4049/jimmunol.168.6.2865. PMID 11884456.
• Mao S, Frank RC, Zhang J, Miyazaki Y, Nimer SD (May 1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias". Molecular and Cellular Biology. 19 (5): 3635–44. doi:10.1128/mcb.19.5.3635. PMC 84165. PMID 10207087.
• Nishiyama C, Takahashi K, Nishiyama M, Okumura K, Ra C, Ohtake Y, Yokota T (Dec 2000). "Splice isoforms of transcription factor Elf-1 affecting its regulatory function in transcription-molecular cloning of rat Elf-1". Bioscience, Biotechnology, and Biochemistry. 64 (12): 2601–7. doi:10.1271/bbb.64.2601. PMID 11210123.
• Tsokos GC, Nambiar MP, Juang YT (Apr 2003). "Activation of the Ets transcription factor Elf-1 requires phosphorylation and glycosylation: defective expression of activated Elf-1 is involved in the decreased TCR zeta chain gene expression in patients with systemic lupus erythematosus". Annals of the New York Academy of Sciences. 987: 240–5. doi:10.1111/j.1749-6632.2003.tb06054.x. PMID 12727645. S2CID 42190457.
• Gunther M, Laithier M, Brison O (Jul 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Molecular and Cellular Biochemistry. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766. S2CID 1339642.
• Yang W, Tang H, Zhang Y, Tang X, Zhang J, Sun L, et al. (Jan 2013). "Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians". American Journal of Human Genetics. 92 (1): 41–51. doi:10.1016/j.ajhg.2012.11.018. PMC 3542470. PMID 23273568.
• Bassuk AG, Anandappa RT, Leiden JM (May 1997). "Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells". Journal of Virology. 71 (5): 3563–73. doi:10.1128/JVI.71.5.3563-3573.1997. PMC 191503. PMID 9094628.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.