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Karim Paul Mahmoud Labib FRSE[1] is a professor at the University of Dundee, studying chromosome duplication and genome integrity. He did his undergraduate at the University of Cambridge in 1989, and his PhD at University of Oxford under Sir Paul Maxime Nurse in 1993.[2] He was a group leader at Paterson Institute for Cancer Research, Cancer Research U.K., Manchester Research Institute from 2001 to 2003, and subsequently moved to the University of Dundee in 2013 as a professor of genome integrity.[3] Karim was elected as a Fellow of the Royal Society of Edinburgh in 2016.[4] He is the Head of the Genome Integrity Division in the University of Dundee. [5]
Karim is investigating how the genetic copying system in cells malfunctions, which can cause cancer. [6] His research focuses on the regulation of the CMG helicase and chromosome replication to understand how proliferating eukaryotic cells preserve genome integrity and maintain epigenetic information.[7] His lab has contributed to the discovery of the GINS Complex and showed that GINS associates with CDC45 and the MCM2-7 ATPases to form the CMG helicase. [8][9][10] His lab proved that DNA replication termination is regulated by CMG helicase ubiquitylation.[11][12]
Honours and awards
edit| Awards | Year |
| Major Personal Funding Awards / Wellcome Discovery Award | 2024 |
| Major Personal Funding Awards / CRUK Programme Discovery Award | 2023 |
| Fellow of the Royal Society of Edinburgh | 2016 |
| Major Personal Funding Awards / CRUK Programme Discovery Award | 2016 |
| Major Personal Funding Awards / Wellcome Investigator Award | 2013 |
| Member of the European Molecular Biology Organisation | 2010 |
| National Sciences Prizes awarded since 1990 / British Society of Cell Biology Hooke Medal | 2010 |
References
edit- ↑ "Professor Karim Labib". Royal Society of Edinburgh. Retrieved 2026-03-26.
- ↑ "Professor Karim Labib | University of Dundee, UK". www.dundee.ac.uk. Retrieved 2026-03-26.
- ↑ "Cell Division Biology - Newcastle University". research.ncl.ac.uk. Retrieved 2026-03-29.
- ↑ "Karim Labib elected Fellow of Royal Society of Edinburgh | MRC PPU". www.ppu.mrc.ac.uk. 2016-03-07. Retrieved 2026-03-26.
- ↑ "Genome Integrity | University of Dundee, UK". www.dundee.ac.uk. Retrieved 2026-03-29.
- ↑ "Business Beats Cancer Dundee | Cancer Research UK". www.cancerresearchuk.org. Retrieved 2026-03-29.
- ↑ "Find people in the EMBO Communities". people.embo.org. Archived from the original on 2025-03-28. Retrieved 2026-03-26.
- ↑ "Karim Labib - Division of Genome Integrity". www.dundeegenomeintegrity.org. Retrieved 2026-03-26.
- ↑ "New paper from Karim Labib's lab reveals the mechanism and regulation of replisome disassembly | MRC PPU". www.ppu.mrc.ac.uk. 2020-08-27. Retrieved 2026-03-26.
- ↑ Gambus, Agnieszka; Jones, Richard C.; Sanchez-Diaz, Alberto; Kanemaki, Masato; van Deursen, Frederick; Edmondson, Ricky D.; Labib, Karim (2006-04-01). "GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks". Nature Cell Biology. 8 (4): 358–366. doi:10.1038/ncb1382. ISSN 1465-7392.
- ↑ Maric, Marija; Maculins, Timurs; De Piccoli, Giacomo; Labib, Karim (2014-10-24). "Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication". Science. 346 (6208). doi:10.1126/science.1253596. ISSN 0036-8075. PMC 4300516. PMID 25342810.
- ↑ Jenkyn-Bedford, Michael; Jones, Morgan L.; Baris, Yasemin; Labib, Karim P. M.; Cannone, Giuseppe; Yeeles, Joseph T. P.; Deegan, Tom D. (2021-12-23). "A conserved mechanism for regulating replisome disassembly in eukaryotes". Nature. 600 (7890): 743–747. doi:10.1038/s41586-021-04145-3. ISSN 0028-0836. PMC 8695382. PMID 34700328.