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Elsa R. Flores is an American cancer biologist whose research examines the p53 family of tumor suppressor genes and their roles in cancer development and therapy resistance.[1] She is a senior member of the Department of Molecular Oncology at the Moffitt Cancer Center in Tampa, Florida, where she also serves as Associate Center Director for the Division of Discovery Science.[2]

Flores's research focuses on the p53 family of transcription factors, particularly p63 and p73, and their roles in apoptosis, DNA repair, and tumor suppression.[3] Science and biotechnology publications have discussed research by Flores on the tumor-suppressive roles of p63 and p73 in cancer progression and metastasis.[4] Her studies have included a pan-cancer analysis showing that the TAp63 protein influences RNA molecules linked to key cancer pathways, including p53 and AKT, and that loss of TAp63 activity can impact tumor development and metastasis.[5]

Her work has also explored how dysfunction in the p53 pathway influences non-coding RNA regulation and cancer metabolism, areas that have been discussed in science and biotechnology publications for their potential therapeutic implications.[3]

Flores joined the Moffitt Cancer Center in 2016 as a senior member of the Department of Molecular Oncology and served as chair of the department from 2016 to 2021. In 2022, she was appointed Associate Center Director of the Division of Discovery Science.[6] Reporting by The Cancer Letter described her appointment as part of Moffitt's broader efforts to expand basic and translational cancer research.[6]

Prior to joining Moffitt, Flores held faculty appointments at the University of Texas MD Anderson Cancer Center beginning in 2004, where she progressed from assistant professor to associate professor.[1]

Early Life and Education

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Flores grew up in Corpus Christi, Texas. She earned a Bachelor of Science degree in chemical engineering from the Massachusetts Institute of Technology and later completed a PhD in cancer biology at the University of Wisconsin–Madison.[7] She subsequently returned to MIT for postdoctoral training at the Koch Institute, where she worked in the laboratory of Tyler Jacks.[4]

Professional Career

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Flores has received research support and honors from organizations including the National Cancer Institute, the American Cancer Society, and the Rita Allen Foundation.[1]

  • 2015 — Outstanding Investigator Award, National Cancer Institute

References

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  1. 1 2 3 "Elsa R. Flores: Pursuing New Pathways to Foil Cancer". Rita Allen Scholars. Rita Allen Foundation.
  2. "Elsa R. Flores, PhD". Moffitt Cancer Center.
  3. 1 2 "Long non-coding RNAs could be future targets for cancer drugs". Drug Target Review. Russell Publishing Limited.
  4. 1 2 Halber, Deborah (10 April 2002). "Team identifies genes in cell suicide". MIT News. Massachusetts Institute of Technology.
  5. Vermes, Krystle (20 October 2020). "Moffitt Cancer Center Sees Breakthrough in Latest Pan-Cancer Analysis". BioSpace.
  6. 1 2 "Elsa Flores named associate center director of basic science at Moffitt". The Cancer Letter. The Cancer Letter, Inc. 14 January 2022.
  7. "Career Advice from Elsa Flores". Career Girls. June 2015.