Discadenine synthase (EC 2.5.1.24) is an enzyme characterised from Dictyostelium discoideum that catalyzes a chemical reaction which converts N6-isopentenyladenine to discadenine. It transfers the 3-amino-3-carboxypropyl group from the coenzyme, S-adenosyl methionine, giving 5'-methylthioadenosine as a byproduct.[1]
| Discadenine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.24 | ||||||||
| CAS no. | 74082-52-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The product discadenine inhibits spore germination in this soil-dwelling amoeba.[1][2]
This enzyme is a transferase, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosyl-L-methionine:N6-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferase. Other names in common use include discadenine synthetase, S-adenosyl-L-methionine:6-N-(Delta2-isopentenyl)-adenine, and 3-(3-amino-3-carboxypropyl)-transferase.[3]
References
edit- 1 2 Taya Y, Tanaka Y, Nishimura S (1978). "Cell-free biosynthesis of discadenine, a spore germination inhibitor of Dictyostelium discoideum". FEBS Lett. 89 (2): 326–8. Bibcode:1978FEBSL..89..326T. doi:10.1016/0014-5793(78)80247-6. PMID 566219.
- ↑ Abe, Hiroshi; Hashimoto, Kazushi; Uchiyama, Masaaki (1981). "Discadenine distribution in cellular slime molds and its inhibitory activity on spore germination". Agricultural and Biological Chemistry. 45 (5): 1295–1296. doi:10.1271/bbb1961.45.1295.
- ↑ Enzyme 2.5.1.24 at KEGG Pathway Database.
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