Dimethylhistidine N-methyltransferase (EC 2.1.1.44) is an enzyme that catalyzes a sequence of methylation reactions:
| Dimethylhistidine N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.44 | ||||||||
| CAS no. | 62213-53-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The overall effect is to convert L-histidine to its trimethylated product, hercynine. Both the singly and doubly methylated compounds are also substrates for the reaction. The methyl groups come from the cofactor, S-adenosyl methionine (SAM), which is converted to S-adenosyl-L-homocysteine (SAH).[1]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine Nalpha-methyltransferase. Other names in common use include dimethylhistidine methyltransferase, histidine-alpha-N-methyltransferase, S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine, and alpha-N-methyltransferase.[2]
In the bacterium Mycobacterium smegmatis, this enzyme is part of the pathway that converts histidine to ergothioneine.[3]
References
edit- ↑ Ishikawa, Yoshinori; Melville, Donald B. (1970). "The Enzymatic α-N-Methylation of Histidine". Journal of Biological Chemistry. 245 (22): 5967–5973. doi:10.1016/S0021-9258(18)62649-3. PMID 5484456.
- ↑ Enzyme 2.1.1.44 at KEGG Pathway Database.
- ↑ Seebeck, Florian P. (2010). "In Vitro Reconstitution of Mycobacterial Ergothioneine Biosynthesis". Journal of the American Chemical Society. 132 (19): 6632–6633. doi:10.1021/ja101721e. PMID 20420449.
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