DPYSL4

Dihydropyrimidinase-related protein 4 is an enzyme that in humans is encoded by the DPYSL4 gene.

DPYSL4
Identifiers
Aliases	DPYSL4, CRMP3, DRP-4, ULIP4, dihydropyrimidinase like 4
External IDs	OMIM: 608407; MGI: 1349764; HomoloGene: 4691; GeneCards: DPYSL4; OMA:DPYSL4 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q26.3 Start 132,186,948 bp End 132,205,759 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F4 Start 138,665,917 bp End 138,682,620 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart ganglionic eminence right frontal lobe endothelial cell prefrontal cortex ventricular zone Brodmann area 9 cingulate gyrus anterior cingulate cortex C1 segment Top expressed in neural tube mesencephalon rhombencephalon cerebellar cortex ovary layer of retina neural layer of retina ventricular zone dentate gyrus of hippocampal formation granule cell primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds filamin binding Cellular component cytoplasm cytosol Biological process neuron death neuron projection guidance nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10570 26757 Ensembl ENSG00000151640 ENSMUSG00000025478 UniProt O14531 O35098 RefSeq (mRNA) NM_006426 NM_011993 RefSeq (protein) NP_006417 n/a Location (UCSC) Chr 10: 132.19 – 132.21 Mb Chr 7: 138.67 – 138.68 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Weitzdoerfer R, Fountoulakis M, Lubec G (2002). "Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down Syndrome brain". Protein Expression in Down Syndrome Brain. pp. 95–107. doi:10.1007/978-3-7091-6262-0_8. ISBN 978-3-211-83704-7. PMID 11771764. {{cite book}}: |journal= ignored (help)
• Fukada M, Watakabe I, Yuasa-Kawada J, et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family". J. Biol. Chem. 275 (48): 37957–65. doi:10.1074/jbc.M003277200. PMID 10956643.
• Inatome R, Tsujimura T, Hitomi T, et al. (2000). "Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain". J. Biol. Chem. 275 (35): 27291–302. doi:10.1074/jbc.M910126199. PMID 10851247.
• Honnorat J, Byk T, Kusters I, et al. (2000). "Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes". Eur. J. Neurosci. 11 (12): 4226–32. doi:10.1046/j.1460-9568.1999.00864.x. PMID 10594648. S2CID 11898553.

External links

• Overview of all the structural information available in the PDB for UniProt: O14531 (Dihydropyrimidinase-related protein 4) at the PDBe-KB.