Cardiotrophin-1 (CT-1) is a protein encoded by the CTF1 gene in humans. It functions as a cytokine and acts as a 21.5 kDa cardiac hypertrophic factor. CT-1 belongs to the IL-6 cytokine family.
Tissue distribution
editCT-1 is highly expressed in the heart, skeletal muscle, prostate and ovary and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine. [5]
Mode of action
editThe protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF-κB DNA -binding activities.
Clinical significance
editCT-1 is associated with the pathophysiology of heart diseases, including hypertension, myocardial infarction, valvular heart disease, and congestive heart failure.
Exogenous administration of CT-1 in rodents has been found to mimic the beneficial effects of exercise on the heart in a rodent model of severe right-sided heart failure.[6][7][8][9][10]
CT-1 is under formal development for the treatment of reperfusion injury.[11] It is or was also under development for treatment of acute kidney injury, diabetes mellitus, ischemia, liver failure, and obesity, but no recent development for these indications has been reported.[11]
See also
editReferences
edit- 1 2 3 GRCh38: Ensembl release 89: ENSG00000150281 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042340 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Recombinant human Cardiotrophin 1 protein (ab9838)". www.abcam.com. Retrieved 2017-08-09.
- ↑ Zelt JG, Chaudhary KR, Cadete VJ, Mielniczuk LM, Stewart DJ (May 2019). "Medical Therapy for Heart Failure Associated With Pulmonary Hypertension". Circ Res. 124 (11): 1551–1567. doi:10.1161/CIRCRESAHA.118.313650. PMID 31120820.
- ↑ Abdul-Ghani M, Suen C, Jiang B, Deng Y, Weldrick JJ, Putinski C, et al. (October 2017). "Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart". Cell Res. 27 (10): 1195–1215. doi:10.1038/cr.2017.87. PMC 5630684. PMID 28785017.
- ↑ How to trick your heart into thinking you exercise, retrieved 15 March 2026
- ↑ Watson SK (10 August 2017). "This protein makes your heart fit without actually exercising it". Popular Science. Retrieved 15 March 2026.
- ↑ Buguliskis JS (8 August 2017). "Fooling the Heart to Be Healthier". GEN - Genetic Engineering and Biotechnology News. Retrieved 15 March 2026.
- 1 2 "Digna Biotech/Biotecnol". AdisInsight. 2 October 2021. Retrieved 15 March 2026.
External links
edit- cardiotrophin+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Irving M (August 8, 2017). "The protein that can make your heart think you exercise". newatlas.com. Retrieved 2017-08-09.
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