Carboxyphosphate (or carboxyphosphoric acid) is a highly unstable mixed anhydride and a metabolic intermediate in nature. It serves as a transient, enzyme bound substance used to transport and transfer carbon dioxide in various biological pathways.[1][2][3]

Carboxyphosphate
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
KEGG
  • acid: InChI=1S/CH3O6P/c2-1(3)7-8(4,5)6/h(H,2,3)(H2,4,5,6)
    Key: LQQCGEGRINLHDP-UHFFFAOYSA-N
  • acid: C(=O)(O)OP(=O)(O)O
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

See also

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References

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  1. Knight, W. B. (1990), Aresta, M.; Schloss, J. V. (eds.), "Carboxyphosphate; Predicted Chemical Properties, Synthesis and Role as an Intermediate in Enzymic Reactions", Enzymatic and Model Carboxylation and Reduction Reactions for Carbon Dioxide Utilization, Dordrecht: Springer Netherlands, pp. 239–258, doi:10.1007/978-94-009-0663-1_14, ISBN 978-94-009-0663-1, retrieved 2026-06-07{{citation}}: CS1 maint: work parameter with ISBN (link)
  2. Wimmer, M. J.; Rose, I. A.; Powers, S. G.; Meister, A. (1979-03-25). "Evidence that carboxyphosphate is a kinetically competent intermediate in the carbamyl phosphate synthetase reaction". The Journal of Biological Chemistry. 254 (6): 1854–1859. doi:10.1016/S0021-9258(17)37734-7. ISSN 0021-9258. PMID 217873.
  3. Powers, S. G.; Meister, A. (1978-02-25). "Carbonic-phosphoric anhydride (carboxy phosphate). Significance in catalysis and regulation of glutamine-dependent carbamyl phosphate synthetase". The Journal of Biological Chemistry. 253 (4): 1258–1265. doi:10.1016/S0021-9258(17)38139-5. ISSN 0021-9258. PMID 203588.