CEMIP

Cell migration-inducing and hyaluronan-binding protein (CEMIP), formerly known as KIAA1199, is a protein that in humans is encoded by the CEMIP gene. CEMIP has been shown to bind hyaluronic acid and catalyze its depolymerization independently of CD44 and hyaluronidases. Such function has also been validated in mice.

CEMIP
Identifiers
Aliases	CEMIP, CCSP1, KIAA1199, TMEM2L, HYBID, cell migration inducing hyaluronan binding protein, cell migration inducing hyaluronidase 1
External IDs	OMIM: 608366; MGI: 2443629; HomoloGene: 10268; GeneCards: CEMIP; OMA:CEMIP - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q25.1 Start 80,779,343 bp End 80,951,776 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 D3|7 48.35 cM Start 83,582,065 bp End 83,735,710 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Epithelium of choroid plexus trigeminal ganglion stromal cell of endometrium tibia pericardium cartilage tissue olfactory bulb lymph node right lobe of thyroid gland left lobe of thyroid gland Top expressed in calvaria vestibular sensory epithelium cranial dura mater stroma of bone marrow body of femur vestibular membrane of cochlear duct stria vascularis trigeminal ganglion gastrula lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function clathrin heavy chain binding ER retention sequence binding hydrolase activity, acting on glycosyl bonds protein binding hyaluronic acid binding hydrolase activity hyalurononglucosaminidase activity Cellular component cytoplasm membrane plasma membrane extracellular region endoplasmic reticulum clathrin-coated pit nucleus clathrin-coated vesicle membrane clathrin-coated endocytic vesicle Biological process hyaluronan biosynthetic process hyaluronan catabolic process positive regulation of cell migration positive regulation of protein kinase C activity positive regulation of release of sequestered calcium ion into cytosol hearing positive regulation of peptidyl-threonine phosphorylation metabolism positive regulation of protein targeting to membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57214 80982 Ensembl ENSG00000103888 ENSMUSG00000052353 UniProt Q8WUJ3 Q8BI06 RefSeq (mRNA) NM_018689 NM_001293298 NM_001293304 NM_030728 RefSeq (protein) NP_001280227 NP_001280233 NP_061159 NP_109653 Location (UCSC) Chr 15: 80.78 – 80.95 Mb Chr 7: 83.58 – 83.74 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

CEMIP is associated with nonsyndromic deafness, as well as a variety of cancers.

Further reading

• Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (October 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (5): 337–345. doi:10.1093/dnares/6.5.337. PMID 10574462.
• Wines ME, Lee L, Katari MS, Zhang L, DeRossi C, Shi Y, et al. (February 2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis". Genomics. 72 (1): 88–98. doi:10.1006/geno.2000.6466. PMID 11247670.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Research. 12 (11): 1773–1784. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Abe S, Katagiri T, Saito-Hisaminato A, Usami S, Inoue Y, Tsunoda T, et al. (January 2003). "Identification of CRYM as a candidate responsible for nonsyndromic deafness, through cDNA microarray analysis of human cochlear and vestibular tissues". American Journal of Human Genetics. 72 (1): 73–82. doi:10.1086/345398. PMC 420014. PMID 12471561.
• Guo J, Cheng H, Zhao S, Yu L (2006). "GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases". FEBS Letters. 580 (2): 581–584. Bibcode:2006FEBSL.580..581G. doi:10.1016/j.febslet.2005.12.076. PMID 16406369. S2CID 1013478.