Beta-phosphoglucomutase

In enzymology, a β-phosphoglucomutase (EC 5.4.2.6) is an enzyme that catalyzes the chemical reaction

β-Phosphoglucomutase
Identifiers
EC no.	5.4.2.6
CAS no.	68651-99-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

β-D-glucose 1-phosphate $\rightleftharpoons$ β-D-glucose 6-phosphate

Hence, this enzyme has one substrate, β-D-glucose 1-phosphate, and one product, β-D-glucose 6-phosphate.

This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is beta-D-glucose 1,6-phosphomutase. This enzyme participates in starch and sucrose metabolism.

Structural studies

20 structures have been solved for this enzyme PDB. Some of the accession codes are 1LVH, 1O03, 1O08, 1Z4N, 1Z4O, and 1ZOL. Most of these structures detail metal fluoride analogue complexes which are used to mimic different states along the reaction coordinate.

References

• Ben-Zvi R, Schramm M (1961). "A phosphoglucomutase specific for beta-glucose 1-phosphate". J. Biol. Chem. 236 (8): 2186–2189. doi:10.1016/S0021-9258(18)64053-0.
• Boyer PD, ed. (1972). The Enzymes. Vol. 6 (3rd ed.). pp. 407–477.