Adenylate dimethylallyltransferase (EC 2.5.1.27) is an enzyme first characterised from tobacco that catalyzes a chemical reaction which converts adenosine monophosphate to N(6)-(dimethylallyl)adenosine 5'-monophosphate. It transfers an isoprenyl group from dimethylallyl pyrophosphate, giving orthophosphate (PPi) as a byproduct. The reaction is part of the pathway to cytokinin plant hormones such as zeatin.[1] the enzyme has also been found in Arabidopsis thaliana and Humulus lupulus.[2][3]
| Adenylate dimethylallyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.27 | ||||||||
| CAS no. | 72840-95-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
-(dimethylallyl)adenosine_5'-monophosphate.svg)
This enzyme is a transferase, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is dimethylallyl-diphosphate:AMP dimethylallyltransferase. Other names in common use include cytokinin synthase, isopentenyltransferase, 2-isopentenyl-diphosphate:AMP Delta2-isopentenyltransferase, and adenylate isopentenyltransferase.[4]
References
edit- ↑ Chen, Chong-maw; Melitz, Debra K. (1979). "Cytokinin biosynthesis in a cell-free system from cytokinin-autotrophic tobacco tissue cultures". FEBS Letters. 107 (1): 15–20. doi:10.1016/0014-5793(79)80452-4. PMID 499537.
- ↑ Takei, Kentaro; Sakakibara, Hitoshi; Sugiyama, Tatsuo (2001). "Identification of Genes Encoding Adenylate Isopentenyltransferase, a Cytokinin Biosynthesis Enzyme, in Arabidopsis thaliana". Journal of Biological Chemistry. 276 (28): 26405–26410. doi:10.1074/jbc.M102130200. PMID 11313355.
- ↑ Sakano, Yuichi; Okada, Yukio; Matsunaga, Akiko; Suwama, Takaharu; Kaneko, Takafumi; Ito, Kazutoshi; Noguchi, Hiroshi; Abe, Ikuro (2004). "Molecular cloning, expression, and characterization of adenylate isopentenyltransferase from hop (Humulus lupulus L.)". Phytochemistry. 65 (17): 2439–2446. doi:10.1016/j.phytochem.2004.08.006. PMID 15381407.
- ↑ Enzyme 2.5.1.27 at KEGG Pathway Database.
