Acridone synthase (EC 2.3.1.159) is an enzyme that catalyzes the chemical reaction
| Acridone synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.159 | ||||||||
| CAS no. | 99085-53-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme combines one unit of N-methylanthraniloyl-CoA with three of malonyl-CoA to produce one unit of 1,3-dihydroxy-N-methylacridone. Four units of coenzyme A and three of carbon dioxide are byproducts of this polyketide synthesis which leads to rutacridone.[1][2] The enzyme was characterised from the plant Ruta graveolens.[3][4]
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing).[5]
References
edit- ↑ Maier W, Baumert A, Schumann B, Furukawa H, Gröger D (1993). "Synthesis of 1,3-dihydroxy-N-methylacridone and its conversion to rutacridone by cell-free extracts of Ruta-graveolens cell cultures". Phytochemistry. 32 (3): 691–698. Bibcode:1993PChem..32..691M. doi:10.1016/S0031-9422(00)95155-0.
- ↑ Baumert A, Maier W, Gröger D, Deutzmann R (1994). "Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L". Z. Naturforsch. C. 49 (1–2): 26–32. doi:10.1515/znc-1994-1-205. PMID 8148006.
- ↑ Matern U; Springob, K; Urbanke, C; Ernwein, C; Schröder, G; Schröder, J; Matern, U (1999). "Native acridone synthases I and II from Ruta graveolens L. form homodimers". FEBS Lett. 448 (1): 135–40. Bibcode:1999FEBSL.448..135L. doi:10.1016/S0014-5793(99)00355-5. PMID 10217426.
- ↑ Junghanns KT, Kneusel RE, Gröger D, Matern U (1998). "Differential regulation and distribution of acridone synthase in Ruta graveolens". Phytochemistry. 49 (2): 403–11. doi:10.1016/S0031-9422(98)00104-6. PMID 9747538.
- ↑ Enzyme 2.3.1.159 at KEGG Pathway Database.
