ASIC3

Acid-sensing ion channel 3 (ASIC3) also known as amiloride-sensitive cation channel 3 (ACCN3) or testis sodium channel 1 (TNaC1) is a protein that in humans is encoded by the ASIC3 gene. The ASIC3 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals. The cDNA of this gene was first cloned in 1998. The ASIC genes have splicing variants that encode different proteins that are called isoforms.

ASIC3
Identifiers
Aliases	ASIC3, ACCN3, DRASIC, SLNAC1, TNaC1, acid sensing ion channel subunit 3
External IDs	OMIM: 611741; MGI: 2159339; HomoloGene: 20999; GeneCards: ASIC3; OMA:ASIC3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q36.1 Start 151,048,292 bp End 151,052,756 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 A3 Start 24,618,390 bp End 24,622,833 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right testis left testis right frontal lobe apex of heart C1 segment anterior pituitary nucleus accumbens caudate nucleus putamen Top expressed in lumbar spinal ganglion neural layer of retina vestibular membrane of cochlear duct cochlea morula trigeminal ganglion embryo embryo blastocyst pineal gland More reference expression data BioGPS n/a
Gene ontology Molecular function PDZ domain binding enterobactin transmembrane transporter activity sodium channel activity cation channel activity ligand-gated sodium channel activity acid-sensing ion channel activity Cellular component cytoplasm integral component of membrane membrane plasma membrane integral component of plasma membrane perinuclear region of cytoplasm Biological process detection of temperature stimulus involved in sensory perception sensory perception sodium ion transmembrane transport detection of chemical stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception sodium ion transport enterobactin transport response to mechanical stimulus cation transport response to heat sensory perception of sour taste ion transport detection of chemical stimulus involved in sensory perception cation transmembrane transport detection of temperature stimulus involved in sensory perception of pain ion transmembrane transport signal transduction response to acidic pH detection of mechanical stimulus involved in sensory perception of pain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9311 171209 Ensembl ENSG00000213199 ENSMUSG00000038276 UniProt Q9UHC3 Q6X1Y6 RefSeq (mRNA) NM_004769 NM_020321 NM_020322 NM_183000 NM_001310474 RefSeq (protein) NP_004760 NP_064717 NP_064718 NP_001297403 NP_892045 Location (UCSC) Chr 7: 151.05 – 151.05 Mb Chr 5: 24.62 – 24.62 Mb PubMed search
Wikidata
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These genes are mainly expressed in the central and peripheral nervous system.

ASICs can form both homotrimeric (meaning composed of three identical subunits) and heterotrimeric channels.

Structure and function

This gene encodes a member of the ASIC/ENaC superfamily of proteins. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane (TM) regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The TM regions are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus).

The pore of the channel through which ions selectively flow from the extracellular side into the cytoplasm is formed by the three TM2 regions of the trimer.

Interactions

ASIC3 has been shown to interact with LIN7B, GOPC, MAGI1, and Ugr 9-1.

Further reading

• Babinski K, Lê KT, Séguéla P (January 1999). "Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties". Journal of Neurochemistry. 72 (1): 51–57. doi:10.1046/j.1471-4159.1999.0720051.x. PMID 9886053. S2CID 10506798.
• Catarsi S, Babinski K, Séguéla P (October 2001). "Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF". Neuropharmacology. 41 (5): 592–600. doi:10.1016/S0028-3908(01)00107-1. PMID 11587714. S2CID 568441.
• Alvarez de la Rosa D, Zhang P, Shao D, White F, Canessa CM (February 2002). "Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system". Proceedings of the National Academy of Sciences of the United States of America. 99 (4): 2326–2331. Bibcode:2002PNAS...99.2326A. doi:10.1073/pnas.042688199. PMC 122364. PMID 11842212.
• Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, Lingueglia E (May 2002). "The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons". The Journal of Biological Chemistry. 277 (19): 16655–16661. doi:10.1074/jbc.M201087200. PMID 11872753.
• Chen CC, Zimmer A, Sun WH, Hall J, Brownstein MJ, Zimmer A (June 2002). "A role for ASIC3 in the modulation of high-intensity pain stimuli". Proceedings of the National Academy of Sciences of the United States of America. 99 (13): 8992–8997. Bibcode:2002PNAS...99.8992C. doi:10.1073/pnas.122245999. PMC 124411. PMID 12060708.
• Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, et al. (February 2003). "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 2029–2034. Bibcode:2003PNAS..100.2029L. doi:10.1073/pnas.252782799. PMC 149953. PMID 12578970.
• Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (November 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". The Journal of Biological Chemistry. 279 (45): 46962–46968. doi:10.1074/jbc.M405874200. PMID 15317815.
• Price MP, Thompson RJ, Eshcol JO, Wemmie JA, Benson CJ (December 2004). "Stomatin modulates gating of acid-sensing ion channels". The Journal of Biological Chemistry. 279 (51): 53886–53891. doi:10.1074/jbc.M407708200. PMID 15471860.
• Jones NG, Slater R, Cadiou H, McNaughton P, McMahon SB (December 2004). "Acid-induced pain and its modulation in humans". The Journal of Neuroscience. 24 (48): 10974–10979. doi:10.1523/JNEUROSCI.2619-04.2004. PMC 6730214. PMID 15574747.
• Su X, Li Q, Shrestha K, Cormet-Boyaka E, Chen L, Smith PR, et al. (December 2006). "Interregulation of proton-gated Na(+) channel 3 and cystic fibrosis transmembrane conductance regulator". The Journal of Biological Chemistry. 281 (48): 36960–36968. doi:10.1074/jbc.M608002200. PMID 17012229.

External links

• Human ASIC3 genome location and ASIC3 gene details page in the UCSC Genome Browser.