5-Hydroxyindole, 5-Indolol or NSC 87503, is an indole alkaloid mood enhancer.[1][2] It is a positive allosteric modulator of the serotonin 5-HT3 receptor.[3]
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3D model (JSmol) |
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| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.016.166 |
| EC Number |
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PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C8H7NO | |
| Molar mass | 133.15 g/mol |
| Related compounds | |
Related compounds |
Indole, 5-Hydroxyindoline, Serotonin |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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References
edit- ↑ "5-Hydroxyindole 97 1953-54-4". Sigmaaldrich.com. Archived from the original on 2022-07-05. Retrieved 2026-06-16.
- ↑ Jakaria, Md; Cannon, Jason R. (July 16, 2025). "The role of hydroxyindoles in protecting neuronal cultures from ferroptosis". Cell Death Discovery. 11 (1): 329. doi:10.1038/s41420-025-02608-4. ISSN 2058-7716. PMC 12267586. PMID 40670345.
- ↑ Newman, Amy S.; Batis, Nikolaos; Grafton, Gillian; Caputo, Francesca; Brady, Catherine A.; Lambert, Jeremy J.; Peters, John A.; Gordon, John; Brain, Keith L.; Powell, Andrew D.; Barnes, Nicholas M. (July 2013). "5-Chloroindole: a potent allosteric modulator of the 5-HT₃ receptor". British Journal of Pharmacology. 169 (6): 1228–1238. doi:10.1111/bph.12213. ISSN 1476-5381. PMC 3831704. PMID 23594147.
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