3alpha-hydroxycholanate dehydrogenase

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3-alpha-hydroxycholanate dehydrogenase
3-alpha-hydroxycholanate dehydrogenase
Identifiers
EC no.	1.1.1.52
CAS no.	9028-57-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

In enzymology, a 3alpha-hydroxycholanate dehydrogenase (EC 1.1.1.52) is an enzyme that catalyzes the chemical reaction

Lithocholic acid

+ NAD⁺

H⁺

Reversible left-right reaction arrow with minor forward product(s) to top right and minor reverse substrate(s) from bottom right

H⁺

2D representation of the chemical structure of Q27073738.

Dehydrolithocholic acid

+ NADH

The two substrates of this enzyme are the bile acid lithocholic acid and nicotinamide adenine dinucleotide (NAD⁺). Its products are dehydrolithocholic acid, NADH, and a proton.^[1]^[2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 3alpha-hydroxy-5beta-cholanate:NAD⁺ oxidoreductase. This enzyme is also called alpha-hydroxy-cholanate dehydrogenase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1IHI.

References

↑ Enzyme 1.1.1.52 at KEGG Pathway Database.
↑ Hayaishi O, Sato Y, Jakoby WB, Stohlman EF (1955). "Reversible enzymatic oxidation of bile acids". Arch. Biochem. 56 (2): 554–5. doi:10.1016/0003-9861(55)90278-2. PMID 14377608.

This EC 1.1.1 enzyme-related article is a stub. You can help Wikipedia by adding missing information.

[1] Enzyme 1.1.1.52 at KEGG Pathway Database.

[2] Hayaishi O, Sato Y, Jakoby WB, Stohlman EF (1955). "Reversible enzymatic oxidation of bile acids". Arch. Biochem. 56 (2): 554–5. doi:10.1016/0003-9861(55)90278-2. PMID 14377608.

[1]

[2]