3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase (EC 1.14.14.12, HsaA) is an enzyme with systematic name 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione,FMNH2:oxygen oxidoreductase.[1] This enzyme catalyses the following chemical reaction:
| 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.12 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O
This bacterial enzyme participates in the degradation of several steroids, including cholesterol and testosterone.
References
edit- ↑ Dresen C, Lin LY, D'Angelo I, Tocheva EI, Strynadka N, Eltis LD (July 2010). "A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism". The Journal of Biological Chemistry. 285 (29): 22264–75. doi:10.1074/jbc.M109.099028. PMC 2903365. PMID 20448045.
External links
edit- 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione+monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
