The preliminary stages of the 2010 Copa Sudamericana de Clubes are:
- First Stage, contested by 16 teams in 8 two-legged ties. The winner of each tie will advance to the Second Stage.
- Second Stage, contested by 30 teams, 8 of whom advanced from the First Stage, in 15 two-legged ties. The winner of each tie will advance to the Round of 16, joining the defending champion, LDU Quito.
First stage
edit| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Colo-Colo |
3–3 (a) | 0–2 | 3–1 | |
| River Plate |
4–4 (a) | 0–2 | 4–2 | |
| Barcelona |
5–2 | 2–1 | 3–1 | |
| Trujillanos |
2–5 | 1–4 | 1–1 | |
| Oriente Petrolero |
3–2 | 2–2 | 1–0 | |
| Olimpia |
1–3 | 0–2 | 1–1 | |
| Universidad San Martín |
(a) 3–3 | 2–3 | 2–1 | |
| Santa Fe |
4–2 | 0–2 | 4–0 |
Match A
edit| Universitario | 2–0 | |
|---|---|---|
| Galindo Lima |
Report |
| Colo-Colo | 3–1 | |
|---|---|---|
| Cámpora Fuenzalida |
Report | Galindo |
Colo-Colo 3–3 Universitario on points. Universitario advanced on away goals.
Match B
edit| Guaraní | 2–0 | |
|---|---|---|
| Fabbro Teixeira |
Report |
| River Plate | 4–2 | |
|---|---|---|
| Ramírez Zambrana Correa |
Report | Teixeira Joel Benítez |
River Plate 3–3 Guaraní on points. Guaraní advanced on away goals.
Match C
edit| Universidad César Vallejo | 1–2 | |
|---|---|---|
| H. Hurtado |
Report | J. Hurtado Noir |
Barcelona advanced on points 6–0.
Match D
edit| Atlético Huila | 4–1 | |
|---|---|---|
| Carbonero Castillo Martínez Velásquez |
Report | R. García |
| Trujillanos | 1–1 | |
|---|---|---|
| R. García |
Report | Rueda |
Atlético Huila advanced on points 4–1.
Match E
edit| Universidad de Chile | 2–2 | |
|---|---|---|
| Bueno Puch |
Report | Rea Saucedo |
Oriente Petrolero advanced on points 4–1.
Match F
edit| Defensor Sporting | 2–0 | |
|---|---|---|
| Mora |
Report |
| Olimpia | 1–1 | |
|---|---|---|
| Ferreyra |
Report | Mora |
Defensor Sporting advanced on points 4–1.
Match G
edit| Deportivo Quito | 3–2 | |
|---|---|---|
| Mina Fernández Checa |
Report | Vitti Alemanno |
| Universidad San Martín | 2–1 | |
|---|---|---|
| Arriola Alemanno |
Report | Checa |
Universidad San Martín 3–3 Deportivo Quito on points. Universidad San Martín advanced on away goals.
Match H
edit| Deportivo Lara | 2–0 | |
|---|---|---|
| Ocanto Chalar |
Report |
| Santa Fe | 4–0 | |
|---|---|---|
| Otálvaro Bernal Noguera Anchico |
Report |
Santa Fe 3–3 Deportivo Lara on points. Santa Fe advanced on goal difference.
Second stage
edit| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| San José |
5–1 | 1–1 | 4–0 | |
| Argentinos Juniors |
1–2 | 0–1 | 1–1 | |
| Peñarol |
3–1 | 1–0 | 2–1 | |
| Palmeiras |
3–2 | 0–2 | 3–0 | |
| Caracas |
1–2 | 1–2 | 0–0 | |
| Avaí |
3–2 | 3–1 | 0–1 | |
| Deportes Tolima |
2–1 | 0–1 | 2–0 | |
| Unión San Felipe |
2–2 (8–7 p) | 1–1 | 1–1 | |
| Banfield |
2–1 | 1–0 | 1–1 | |
| Emelec |
6–2 | 1–2 | 5–0 | |
| Atlético Mineiro |
1–0 | 0–0 | 1–0 | |
| Cerro Porteño |
2–3 | 0–1 | 2–2 | |
| Grêmio |
1–3 | 1–1 | 0–2 | |
| Sport Huancayo |
2–9 | 0–9 | 2–0 | |
| Estudiantes |
1–2 | 0–1 | 1–1 |
Match O1
edit| Atlético Huila | 1–1 | |
|---|---|---|
| Martínez |
Report | de Souza |
| San José | 4–0 | |
|---|---|---|
| Villalba de Souza Bejarano Medina |
Report |
San José advanced on points 4-1.
Match O2
edit| Argentinos Juniors | 1–1 | |
|---|---|---|
| Ortigoza |
Report | Gracián |
Independiente advanced on points 4–1.
Match O3
editMatch O4
edit| Palmeiras | 3–0 | |
|---|---|---|
| Tadeu Marcos Assunção |
Report |
Palmeiras 3–3 Vitória on points. Palmeiras advanced on goal difference.
Match O5
editMatch O6
edit| Avaí | 0–1 | |
|---|---|---|
| Report | Zé Eduardo |
Avaí 3–3 Santos on points. Avaí advanced on goal difference.
Match O7
edit| Deportes Tolima | 2–0 | |
|---|---|---|
| Medina Perlaza |
Report |
Deportes Tolima 3–3 Oriente Petrolero on points. Deportes Tolima advanced on goal difference.
Match O9
editUnión San Felipe 3–3 Guaraní on points. Unión San Felipe advanced 8–7 on penalties.
Match O10
edit| Vélez Sársfield | 0–1 | |
|---|---|---|
| Report | García |
| Banfield | 1–1 | |
|---|---|---|
| Carrusca |
Report | Cristaldo |
Banfield advanced on points 4–1.
Match O11
edit| Universidad San Martín | 2–1 | |
|---|---|---|
| Vitti Quinteros |
Report | Rojas |
| Emelec | 5–0 | |
|---|---|---|
| Ayoví Quiroz Giménez Valencia |
Report |
Emelec 3–3 Universidad San Martín on points. Emelec advanced on goal difference.
Match O12
edit| Atlético Mineiro | 1–0 | |
|---|---|---|
| Ricardinho |
Report |
Atlético Mineiro advanced on points 4–1.
Match O13
edit| Universitario | 1–0 | |
|---|---|---|
| Galindo |
Report |
| Cerro Porteño | 2–2 | |
|---|---|---|
| dos Santos Núñez |
Report | Galindo Cirillo |
Universitario advanced on points 4–1.
Match O14
editMatch O15
edit| Defensor Sporting | 9–0 | |
|---|---|---|
| de Souza Risso Amado Mora Luna Aranda |
Report |
Note: This is the largest margin of victory in the history of the Copa Sudamericana.
| Sport Huancayo | 2–0 | |
|---|---|---|
| Suárez Ramírez |
Report |
Sport Huancayo 3–3 Defensor Sporting on points. Defensor Sporting advanced on goal difference.
Match O16
edit| Newell's Old Boys | 1–0 | |
|---|---|---|
| Formica |
Report |
| Estudiantes | 1–1 | |
|---|---|---|
| Fernández |
Report | Borghello |
Newell's Old Boys advanced on points 4–1.