2-hydroxycyclohexanone 2-monooxygenase (EC 1.14.13.66) is an enzyme that catalyzes the chemical reaction
| 2-hydroxycyclohexanone 2-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.66 | ||||||||
| CAS no. | 62628-31-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The four substrates of this enzyme are 2-hydroxycyclohexan-1-one, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen, and a proton. Its products are 6-hydroxyhexano-6-lactone, oxidised NADP+, and water.[1][2]
This enzyme is an oxidoreductase, acting on paired donors, with molecular oxygen as oxidant and incorporating one of its atoms. The systematic name of this enzyme class is 2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing). The product spontaneously forms 6-oxohexanoic acid and in Acinetobacter this can be further oxidised to adipic acid.[2]
References
edit- ↑ Enzyme 1.14.13.66 at KEGG Pathway Database.
- 1 2 Davey JF, Trudgill PW (1977). "The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species". Eur. J. Biochem. 74 (1): 115–27. doi:10.1111/j.1432-1033.1977.tb11373.x. PMID 856571.
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