2-aminobenzenesulfonate 2,3-dioxygenase (EC 1.14.12.14) is an enzyme that catalyzes the chemical reaction
| 2-aminobenzenesulfonate 2,3-dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.12.14 | ||||||||
| CAS no. | 156621-16-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The four substrates of this enzyme are orthanilic acid, reduced nicotinamide adenine dinucleotide (NADH), oxygen and a proton. Its products are 2,3-dihydroxybenzenesulfonic acid, oxidised NAD+, and ammonia.[1][2]
This enzyme is an oxidoreductase that uses molecular oxygen as oxidant and incorporates both its atoms into the starting material. The systematic name of its class is 2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming). It is also called 2-aminosulfobenzene 2,3-dioxygenase. It can degrade a variety of benzenesulfonic acids.[3]
References
edit- ↑ Enzyme 1.14.12.14 at KEGG Pathway Database.
- ↑ Junker F, Field JA, Bangerter F, et al. (June 1, 1994). "Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid". Biochem. J. 300 (Pt 2): 429–36. doi:10.1042/bj3000429. PMC 1138180. PMID 8002948.
- ↑ Junker F, Leisinger T, Cook AM (July 1994). "3-Sulphocatechol 2,3-dioxygenase and other dioxygenases (EC 1.13.11.2 and EC 1.14.12.-) in the degradative pathways of 2-aminobenzenesulphonic, benzenesulphonic and 4-toluenesulphonic acids in Alcaligenes sp. strain O-1". Microbiology. 140 (7): 1713–22. doi:10.1099/13500872-140-7-1713. PMID 8075807.
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