| Date | Time | Opponent | Site | TV | Result | Attendance | Source |
|---|
| September 11 | 12:00 pm | at Army* | | FSN | W 34–15 | 29,646 | |
| September 18 | 7:00 pm | at Virginia | | ESPN2 | L 7–35 | 50,000 | |
| September 25 | 12:00 pm | No. 25 NC State | | JPS | W 31–7 | 23,450 | |
| October 2 | 6:30 pm | Rutgers* | - Groves Stadium
- Winston-Salem, NC
| | W 17–10 | 20,772 | |
| October 9 | 12:00 pm | Maryland | - Groves Stadium
- Winston-Salem, NC
| JPS | L 14–17 | 19,321 | |
| October 16 | 7:00 pm | at No. 1 Florida State | | | L 10–33 | 78,105 | |
| October 23 | 3:30 pm | UAB* | - Groves Stadium
- Winston-Salem, NC
| | W 47–3 | 20,578 | [2] |
| October 30 | 12:00 pm | Clemson | - Groves Stadium
- Winston-Salem, NC
| JPS | L 3–12 | 21,105 | |
| November 6 | 1:30 pm | at North Carolina | | | W 19–3 | 40,000 | |
| November 13 | 1:30 pm | at Duke | | | L 35–48 | 29,457 | |
| November 20 | 3:30 pm | No. 14 Georgia Tech | - Groves Stadium
- Winston-Salem, NC
| | W 26–23 | 25,230 | |
| December 25 | 3:30 pm | vs. Arizona State* | | ABC | W 23–3 | 40,974 | |
- *Non-conference game
Homecoming- Rankings from AP Poll released prior to the game
- All times are in Eastern time
|
| 1999 Wake Forest Demon Deacons football team roster |
| Players |
Coaches |
| Offense
|
Defense
|
Special teams
|
- Head coach
- Coordinators/assistant coaches
- Legend
- (C) Team captain
- (S) Suspended
- (I) Ineligible
Injured
Redshirt
Roster |
| Category | Team Leader | Att/Cth | Yds |
| Passing | Ben Sankey | 133/224 | 1,496 |
| Rushing | Morgan Kane | 275 | 1,161 |
| Receiving | Jammie Deese | 32 | 444 |