| Date | Time | Opponent | Rank | Site | TV | Result | Attendance |
|---|
| September 14 | 1:05 p.m. | Central Michigan* | No. 18 | | | L 3–20 | 71,629 |
| September 21 | 2:30 p.m. | at No. 11 Notre Dame* | | | NBC | L 10–49 | 59,075 |
| September 28 | 1:05 p.m. | Rutgers* | | - Spartan Stadium
- East Lansing, MI
| | L 7–14 | 67,636 |
| October 5 | 2:00 p.m. | at Indiana | | | | L 0–31 | 46,882 |
| October 12 | 12:30 p.m. | No. 5 Michigan | | - Spartan Stadium
- East Lansing, MI (rivalry)
| ESPN | L 28–45 | 80,157 |
| October 19 | 1:05 p.m. | Minnesota | | - Spartan Stadium
- East Lansing, MI
| | W 20–12 | 75,097 |
| October 26 | 3:30 p.m. | at No. 14 Ohio State | | | ABC | L 17–27 | 94,341 |
| November 2 | 1:05 p.m. | Northwestern | | - Spartan Stadium
- East Lansing, MI
| | L 13–16 | 64,991 |
| November 9 | 2:00 p.m. | at Wisconsin | | | | W 20–7 | 41,074 |
| November 16 | 1:00 p.m. | at Purdue | | | | L 17–27 | 30,744 |
| November 23 | 1:05 p.m. | Illinois | | - Spartan Stadium
- East Lansing, MI
| | W 27–24 | 61,721 |
- *Non-conference game
Homecoming- Rankings from AP Poll released prior to the game
- All times are in Eastern time
|
| 1991 Michigan State Spartans football team roster |
| Players |
Coaches |
| Offense
|
Defense
| Pos. | # | Name | Class |
| SS |
24 |
Myron Bell |
So |
| LB |
41 |
Chuck Bullough |
Sr |
| LB |
45 |
Matt Christensen |
| DT |
93 |
Mike Edwards |
Jr |
| LB |
83 |
Rob Fredrickson |
So |
| CB |
23 |
Alan Haller |
Sr |
| DT |
99 |
Willie Hill |
Jr |
| DE |
96 |
Bill Johnson |
Sr |
| FS |
2 |
Corey Keyes |
So |
| DE |
84 |
John MacNeill |
Sr |
| DT |
91 |
Ed O'Bradovich |
Sr |
| FS |
33 |
Brian Vooletich |
Sr |
| SS |
37 |
Steve Wasylk |
So |
| DB |
18 |
Brian Winters |
So |
|
Special teams
|
- Head coach
- Coordinators/assistant coaches
- Legend
- (C) Team captain
- (S) Suspended
- (I) Ineligible
Injured
Redshirt
|