1925 U.S. National Championships – Women's singles

First-seeded Helen Wills defeated Kathleen McKane Godfree 3–6, 6–0, 6–2 in the final to win the women's singles tennis title at the 1925 U.S. National Championships. The event was held at the West Side Tennis Club, Forest Hills, New York City. It was Wills's third consecutive U.S. National singles title.

Women's singles
1925 U.S. National Championships
Champion	Helen Wills
Runner-up	Kathleen McKane Godfree
Score	3–6, 6–0, 6–2
Draw	64

Draw

Final eight

	Quarterfinals							Semifinals							Finals
		Elizabeth Ryan	6	5	2
		Kathleen McKane Godfree	3	7	6
									Kathleen McKane Godfree	4	7	8
									Molla Bjurstedt Mallory	6	5	6
		Molla Bjurstedt Mallory	6	6
		Penelope Anderson	2	1
																Kathleen McKane Godfree	6	0	2
																Helen Wills	3	6	6
		Helen Wills	4	6	6
		Joan Fry	6	0	3
									Helen Wills	3	6	6
									Eleanor Goss	6	0	2
		Eleanor Goss	6	11
		Dorothea Douglass Lambert Chambers	2	9