Talk:Serotonin–norepinephrine–dopamine reuptake inhibitor

Article deletion

Many years ago, this article was focused on its title subject (as 99.9999% of encyclopedia articles are), noting that SNDRIs are a new frontier in psychopharmacology and that only a few are in clinical trials. Now it has transformed into an article encompassing every pharmacological class of medication. The entire purpose of having a separate article for a particular topic is to elucidate aspects that might come across as unnecessary detail when covering its broader, related/inclusive topic. If I knew nothing about psychopharmacology, I would be horribly confused after reading this. At best, this article is redundant; at worse, it is obfuscating the very subject it purports to clarify. This page, as of 2015 Dec 17, is unfit for publication and should be either revised or rewritten from scratch.Frostlark (talk) 17:31, 17 December 2015 (UTC)

This was formerly a much longer article. This longer version may be found in the history.

This article is complete and utter garbage. It seems like it was written entirely by one person, and that person seems very biased, ignorant and pretentious. —Preceding unsigned comment added by 72.200.115.120 (talk) 07:15, 2 October 2009 (UTC)

References list

Long list of references

Depression (Part 1) Guest Editors: John H. Kehne and Ronald S. Duman (April 07)

New approaches to antidepressant drug discovery: beyond monoamines. Olivier Berton and Eric J. Nestler

The Genetics of Depression: A Review (Jul '06)

The Mesolimbic Dopamine Reward Circuit in Depression (Jun 06)

Serotonin Receptors as Targets in Drug Discovery and Medicinal Chemistry (Sep '06)

Serotonin-Dopamine Interaction as a Focus of Novel Antidepressant Drugs (feb 06)

Neurotransmitter transporters and their impact on the development of psychopharmacology. Iversen Br J Pharmacol 147: S82-S88 2006

Serotonin Reuptake Inhibitors: The Corner Stone in Treatment of Depression for Half a Century - A Medicinal Chemistry Survey.

Serotonin (5HT), Fluoxetine, Imipramine and Dopamine Target Distinct 5HT Receptor Signaling to Modulate Caenorhabditis elegans Egg-Laying Behavior Ji Ying Sze1 2005

Neuronal Targets of Cocaine

Dopamine

Nucleus Accumbens D2/3 Receptors Predict Trait Impulsivity and Cocaine Reinforcement (2007) J. Dalley

Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys. (2007)

D2-Autoreceptors Chronically Enhance Dopamine Neuron Pacemaker Activity J Neurosci 2006 May 10; 26(19): 5240–5247.

Cooperative activation of D1- and D2-like DA receptors in the NAc shell is required for cocaine-seeking behavior in the rat (06) H.D. Schmidt

Cocaine Cues and Dopamine in Dorsal Striatum: Mechanism of Craving in Cocaine Addiction (2006)

Changes in extracellular dopamine during cocaine self-administration in squirrel monkeys. Synapse, 56:129-134, 2005.

Dopamine and drug addiction: the nucleus accumbens shell connection. Gaetano Di Chiara, Valentina Bassareoa, Sandro Fenua, Maria Antonietta De Lucaa, Liliana Spinaa, Cristina Cadonia, Elio Acquasa, Ezio Carbonia, Valentina Valentinia and Daniele Leccaa 2004.

Norepinephrine

Difference in magnitude of psychostimulant-induced extracellular norepinephrine in the ventral tegmental area contributes to discrepant prefrontal dopamine outflow Pan WH, Hsieh MC, Wu HH, Lin SK. Addict Biol. 2007 Mar;12(1):51-8.

Alpha-Noradrenergic Receptors Modulate the Development and Expression of Cocaine Sensitization (2006).

Role of the increased noradrenergic neurotransmission in drug self-administration. Wee S, Wang Z, He R, Zhou J, Kozikowski AP, Woolverton WL. 2005

Neurochemical interaction between dopaminergic and noradrenergic neurons in the medial prefrontal cortex Wynn Pan, Sze-Yuan Yang, Shi-Kwang Lin

Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Gainetdinov 2000

Noradrenergic involvement in the discriminative stimulus effects of cocaine in squirrel monkeys (95 Spealman)

Serotonin

Effects of Combined Dopamine and Serotonin Transporter Inhibitors on Cocaine Self-Administration in Rhesus Monkeys. (2007)

Development of a Rationally Designed, Low Abuse Potential, Biogenic Amine Releaser That Suppresses Cocaine Self-Administration ('05)

Relationship between the Serotonergic Activity and Reinforcing Effects of a Series of Amphetamine Analogs (2005)

Role of serotonin in cocaine effects in mice with reduced dopamine transporter function. PNAS, January 6, 2004; 101(1): 372-377.

Serotonin1B Receptors in the Ventral Tegmental Area Modulate Cocaine-Induced Increases in Nucleus Accumbens Dopamine Levels 04

Serotonergic Attenuation of the Reinforcing and Neurochemical Effects of Cocaine in Squirrel Monkeys. JPET 2002 300: 831-837.

The serotonergic and noradrenergic effects of antidepressant drugs are anticonvulsant, not proconvulsant. Ronald B.P. Jobe 2005

σ–Receptors

σ Receptors: potential medications development target for anti-cocaine agents (03) Matsumoto

Involvement of sigma receptors in the behavioral effects of cocaine: evidence from novel ligands and antisense oligodeoxynucleotides R. Matsumoto, K. McCracken (2002).

Cholinergic

Pharmacological Characterization of Nicotine's Interaction with Cocaine and Cocaine Analogs J Pharmacol Exp Ther 1999 289: 1229-1236.

Ritz* Cocaine toxicity: concurrent influence of dopaminergic, muscarinic and sigma receptors in mediating cocaine-induced lethality '97

Ritz* Cocaine-induced convulsions: pharmacological antagonism at serotonergic, muscarinic and sigma receptors '97

Na+ Channels

In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys. (2005)

On the relationship between the dopamine transporter and the reinforcing effects of local anesthetics in rhesus monkeys. (2000)

Ionotropic Glutamate Receptors

AMPA and NMDA Receptors in P2 Fractions of Cocaine and Cocaine–Prazosin-Treated Rats August 2006

Reduction of Corticostriatal Glutamatergic Fibers in Basic Fibroblast Growth Factor Deficient Mice is Associated with Hyperactivity and Enhanced Dopaminergic Transmission Dec 2006

Repeated cocaine administration differentially affects NMDA receptor subunit (NR1, NR2A-C) mRNAs in rat brain Mika Yamaguchi 1 2, Toshihito Suzuki 1 2 *, Shuzo Abe 2, Takafumi Hori 2, Hirofumi Kurita 2, Takashi Asada 2, Nobuo Okado 3, Heii Arai '02

Article re-written

I've re-written some of the article to remove irrelevant information and outdated clinical candidates. I've shrunk the size of the article significantly, however I think that perhaps adding more information about the three relevant neurotransmitters roles in depression would be useful. It also needs more citations. Comrinec (talk) 16:40, 6 June 2010 (UTC)

Still too large article for such a small class of substances which includes especially cocaine

Most of the substances mentioned in the article are not triple "Serotonin-norepinephrine-dopamine reuptake inhibitors" "SNDRI". The article makes a long review of many other classes which are not at all "SNDRI". It speaks about MAOI, SSRI, SNRI which all of them are not at all "SNDRI" and have no relevance to the item. The main and most known "SNDRI" is cocaine, which is a psychostimulant abuse substance and recreational drug, which causes a high and dangerous craving, compulsive drug seeking, associated with the activation of specific reward structures in the brain, with daily or binges abuse, often dependence, intoxications with potential agitation, anxiety. paranoia or agressiveness, discontinuation syndromes often with severe depression. The presence of SSRi, SNRI, and other antidepressive medications which are not "SNDRI", and are not abusable substance, only is producing confusion among the readers, confusion between pharmacological treatment and substance abuse.Ewan2 (talk) 21:43, 4 July 2014 (UTC)

Dimebon

The part about magic bullet pharmaceutical drugs which gives dimebon as an example of an expecially efficient drug is contrary to new research about this substance and is also contradictory to the Wikipedia article on dimebon. — Preceding unsigned comment added by 217.209.169.236 (talk) 12:56, 14 January 2017 (UTC)

I've fixed this. Seppi333 (Insert 2¢) 22:52, 14 January 2017 (UTC)

Wiki Education assignment: BIOL 412 HONORS

This article was the subject of a Wiki Education Foundation-supported course assignment, between 24 January 2025 and 25 April 2025. Further details are available on the course page. Student editor(s): Annasnags2025 (article contribs).

— Assignment last updated by Littorina littorea (talk) 18:36, 23 February 2025 (UTC)

Tore out a bunch of stuff. This needs a lot of work

This article has a lot of problems. I've gone ahead and ripped out the long diatribes (I feel a bad mass deleting, but there was just way too much to find what little was worth keeping. Sorry man!). This shouldn't feature information on the 3 neurotransmitters, and definitely not on every kind of antidepressant, they have their own dedicated pages.

I've mainly just focused on cutting out stuff, so the formatting is still messed up.

Also, do we need a super long section on every single SNDRI? I dont see how that is remotely relevant to 99% of readers. SelSalt (talk) 04:52, 27 June 2026 (UTC)

I've further removed the section on addiction, as it's contents are better suited by the addiction article. I wish I could add a replacement, but I'm not qualified to write about how SNDRIs interact with reward systems. If you're qualified, please add a section about this! SelSalt (talk) 21:00, 28 June 2026 (UTC)